Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 TherapyArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 receptor Activation activities alleviate Alleviating alveolar antioxidant antiviral role conformational change COVID-19 Cytokine storm Dipeptidyl peptidase 4 Direct dosage Endothelium favor furin Helicase host receptor hyperinflammation Illness severity immunogenic Inflammatory Inflammatory responses influences membranes Organ failure oxidative stress Papain-like protease pathology pathway protease reactive oxygen specy Receptor binding domain Replication risk RNA-dependent RNA polymerase role serine 2 the spike protein transmembrane vicious cycle viral spike protein [DOI] 10.1021/acs.jmedchem.2c01134 PMC 바로가기
Defying convention in the time of COVID-19: Insights into the role of γδ T cellsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] acute respiratory syndrome adaptive immune responses aminobisphosphonates COVID-19 antiviral role Autoimmunity caused Cell circulating clearance Clinical outcome complex contribute coronavirus Coronavirus disease 2019 COVID-19 Critical Cytokine storm demonstrated disease Diseases function Gamma gamma delta (γδ) T cells immune response impede Infection Innate immunity insight less lung mucosal tissues Patient respiratory viral infection SARS-CoV-2 SARS-COV-2 infection severe cases Surveillance T cell T cell response T lymphocyte [DOI] 10.3389/fimmu.2022.819574 PMC 바로가기
Anti-MDA5 Antibody Linking COVID-19, Type I Interferon, and Autoimmunity: A Case Report and Systematic Literature ReviewCOVID-19, I형 인터페론 및 자가면역을 연결하는 항MDA5 항체: 증례 보고 및 체계적인 문헌 검토Case Reports Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation anti-MDA5 syndrome antibody antiviral role Autoimmune Autoimmune disease Autoimmune diseases Cardiomyopathy Clinical features constitutional symptoms contribute correlated COVID-19 COVID-19 severity Cytokines differentiation antigen disease Disease activity elevated example explain Features IFN immune immune response immunological immunology in some induce Inflammatory inflammatory myositis interferons literature lung involvement Manifestations MDA5 mechanisms Melanoma myositis Patient Pattern recognition pattern recognition receptor protective effect Protective effects recognizing report review SARS-CoV-2 infected patients SARS-COV-2 infection searched severity signature similarities similarity skin manifestations Symptoms syndrome synthesis Trigger Type Type I IFN type I interferon type I interferon signature. type I interferons Viral viral infections virus viruses while with COVID-19 [DOI] 10.3389/fimmu.2022.937667 PMC 바로가기 [Article Type] Case Reports
Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 아유르베다 전통 약용 식물의 항바이러스 활성Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptor amarogentin Analysis angiotensin Antiviral antiviral activity antiviral role apoptotic pathway approach attachment inhibitor Ayurveda belladonnine COVID-19 criteria demonstrated disease drug design drug-likeness drug-target interaction Drug-target interactions Efficacy etiological agent G-protein gene network gene network analysis highest affinity Host membrane protein MOST Necrosis network analysis nuclear parameter pathway Pathways pharmacokinetic pharmacokinetics Phosphorylation plant positive potential therapy predicted Protein protein kinase Protein kinase B receptor Regulation responsible SARS-CoV-2 SARS-COV-2 infection secretion Serine Signaling spike glycoprotein Structure-based drug design suggested target target prediction. Toxicity Transport Tumor tumor necrosis tumor necrosis factor Vaccine was performed [DOI] 10.1080/07391102.2020.1832577 PMC 바로가기 [Article Type] Article
miRNA-223 as a regulator of inflammation and NLRP3 inflammasome, the main fragments in the puzzle of immunopathogenesis of different inflammatory diseases and COVID-19염증 조절제로서의 miRNA-223 및 다양한 염증성 질환 및 COVID-19의 면역 병인 발생 퍼즐의 주요 단편인 NLRP3 인플라마좀Review Published on 2021-11-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress syndrome antioxidant antiviral role caspase caspase-1 CCL3 Control COVID-19 CXCL2 distress Factors feature FOXO1 genomic sequence HDAC2 IFN-I IKKα IL-18 IL-1β IL-6 Immunopathogenesis implicated infection with SARS-CoV-2 Inflammation inflammatory disease inflammatory process involved ITGB3 lung Lung injury mechanism miR-223 miR-223. miRNA monocyte-macrophage neutrophil neutrophil recruitment NF-κB NLRP3 NLRP3 inflammasome PARP PI3K pro-inflammatory responses Regulatory remained respiratory distress Respiratory distress syndrome SARS-CoV-2 STMN1 TLR4 Traf6 variety with COVID-19 [DOI] 10.1007/s00210-021-02163-6 PMC 바로가기 [Article Type] Review
Synthesis and characterization of new thiazole-based Co(II) and Cu(II) complexes; therapeutic function of thiazole towards COVID-19 in comparing to current antivirals in treatment protocolResearch article Published on 2021-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료법, 치료제, [키워드] analogue analogues Antiviral antiviral activity antiviral role carried characterized complex complexes COVID-19 COVID-19 drugs COVID-19 pandemic DFT drug drugs effective Efficiency ESR form in-silico Interaction ions Ligand metal ions molecular docking Neutral outcome pandemic pharmacophore profile Proteins suggested Support synthesis therapeutic Thiazol complexes Treatment Treatment protocol while [DOI] 10.1016/j.molstruc.2021.130961 [Article Type] Research article
The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule FormationCellular Response to Infection Published on 2021-10-132022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] activate activated activating Activation acute respiratory syndrome addition antiviral drugs antiviral role Betacoronavirus cause caused Cell Characteristics coronavirus Coronavirus replication coronavirus-infected cell coronavirus-infected cells Coronaviruses decrease disease Diseases double-stranded eIF2α eIF2α Encephalomyelitis Endoplasmic reticulum endoplasmic reticulum stress ER stress facilitate Facilitating Formation Granule high mortality rate Host Human in vitro in vivo infected cells Infection inhibited innate response Interaction interferon invading pathogen mechanism MERS-CoV Middle East modulate nerve cell neurotropic new treatment strategy Occurrence outcome pathogenic pathway Phosphorylation PKR porcine hemagglutinating encephalomyelitis virus promoted Protein protein translation regulate regulated Replication repressed respiratory syndrome coronavirus reveal SARS-CoV SARS-CoV-2 signaling pathway specific treatment stress granule suppressed target translation attenuation triggered turn unfolded protein response UPR viral proliferation viral replication virus [DOI] 10.1128/JVI.01695-21 PMC 바로가기 [Article Type] Cellular Response to Infection
Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1423 Published on 2021-09-142022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] addressed antiviral role Bioinformatics analysis catalytic activity caused Cell cleavage cleave cleaved complex conserved coronavirus Coronavirus replication COVID-19 decrease Degradation develop drug ENhance enzyme Evidence evidenced facilitate Factors finger global public health Host host antiviral response host protein identify inhibitor interferon interferon-stimulated gene ISGs knockdown M pro mutant nsp5 polyprotein Prevent promote protease provided Respiratory Coronavirus Ring risk RNA interference RNF20 RNF40 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease SARS-CoV-2 replication Significance significantly SREBP1 stimulatory target treat viral replication [DOI] 10.1073/pnas.2107108118 PMC 바로가기 [Article Type] 423
Immunomodulatory Role of Nutrients: How Can Pulmonary Dysfunctions Improve?Nutrition Published on 2021-09-072022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activating acute respiratory syndrome addition Affect allergies Anti-inflammatory Anti-inflammatory effects antioxidant antiviral role Asthma Can can be used changes chronic disease chronic inflammatory disease chronic inflammatory diseases chronic lung diseases chronic obstructive Complication Compound contribute COPD coronavirus COVID-19 decrease deficiency Diseases Effect Epigenetic Factor fatty acids HDAC Health Health status help homeostasis immune response immune system IMPROVE in vitro Infection infections Inflammatory response influence inhibit involved lower risk lung Lung function lung health mechanism microbiota mineral Modification modulate Nutrients nutrition Pathogens Patient patients Perspective progression proinflammatory cytokines promote pulmonary pulmonary chronic diseases pulmonary complication pulmonary disease pulmonary viral reducing Regulatory risk role SARS-CoV-2 SARS-COV-2 infection severe disease shown substrate Transcription Treatment viral infections viral replication Vitamin vitamins [DOI] 10.3389/fnut.2021.674258 PMC 바로가기 [Article Type] Nutrition
Host-dependent editing of SARS-CoV-2 in COVID-19 patientsCOVID-19 환자에서 SARS-CoV-2의 호스트 의존적 편집Research Article Published on 2021-09-052022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, [키워드] acting ADAR1 adenosine adenosine deaminase affected Analysis antiviral role caused coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient editing fixed fraction frequencies Frequency genetic variability genomes Host human population Illumina infected individuals Infection investigated long-lasting mechanism mechanisms Mild MOST Mutation mutations new SARS-CoV-2 Next-generation sequencing NGS Non-synonymous Nsp12 Patient persistent infection platform predominant produced Quasispecies Replication RNA virus RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants Sequencing severe disease Single nucleotide polymorphism single nucleotide polymorphisms spike gene Substitution the SARS-CoV-2 Variability variant variants Viral Viral quasispecies viral quasispecy Viremia viruses [DOI] 10.1080/22221751.2021.1969868 PMC 바로가기 [Article Type] Research Article