Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretionOriginal Article Published on 2023-11-302024-09-05 Journal: Mol Metab [Category] update2024, [키워드] Apolipoprotein Lipid absorption Lipid secretion lipoprotein small intestine SURF4 [DOI] 10.1016/j.molmet.2023.101847 PMC 바로가기 [Article Type] Original Article
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article
Association of Apolipoprotein e polymorphism with SARS-CoV-2 infectionSARS-CoV-2 감염과 아포지단백 e 다형성의 연관성Article Published on 2021-11-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 allele alleles Apolipoprotein Apolipoprotein e association Asymptomatic candidate gene caused Coronavirus-2 COVID-19 COVID-19 disease COVID-19 infection COVID-19 patients disease disease symptoms Epsilon General population Genetic polymorphism Genotype Host genetic factor human body Iraq morbidity and mortality pandemic PCR polymorphism required responses SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe symptoms suggested Symptoms the disease thought viral disease with COVID-19 [DOI] 10.1016/j.meegid.2021.105043 PMC 바로가기 [Article Type] Article
Prognostic value of apolipoproteins in COVID-19 patients: A systematic review and meta-analysisReview article Published on 2021-11-012022-10-05 Journal: Travel medicine and infectious disease [Category] SARS, 바이오마커, [키워드] 95% confidence interval 95%CI all-cause mortality analyzed ApoA ApoB Apolipoprotein association Biomarker Cerebrovascular disease CIs cohort study conducted COVID-19 COVID-19 patients COVID-19 severity Diseases Effect high risk higher odd higher risk Meta-analysis Mortality neoplasm observational study Odds ratio Predictive Prognosis prognostic biomarker protective factor reported Result risk of bia SARS-CoV-2 severe disease severity shown statistically significant systematic review utility was used [DOI] 10.1016/j.tmaid.2021.102200 [Article Type] Review article
Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2Commentary Published on 2021-07-162022-10-29 Journal: Medicines [Category] COVID-19, [키워드] antiviral activity apoA-I apoA-II Apolipoprotein COVID-19 Critical Glycation HDL high-density High-density lipoproteins Importance lipoprotein Potential SARS-CoV-2 SARS-COV-2 infection SR-BI [DOI] 10.3390/medicines8070038 PMC 바로가기 [Article Type] Commentary
Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA2019년 코로나바이러스 질병(COVID-19)에서 조절되지 않는 염증성, 혈전성, 항섬유소용해 상태 및 심각한 급성 신장 손상의 발달과 관련된 지질 프로필의 변화: 미국 신시내티의 연구Article Published on 2021-05-012022-09-11 Journal: Diabetes & metabolic syndrome [Category] SARS, 바이오마커, [키워드] Acute kidney injury ADAMTS13 AKI alteration analyzed Apolipoprotein Apolipoproteins association Biomarkers Cincinnati Control coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 cohort COVID-19 patient COVID-19 patients creatinine CRP decrease Department Deterioration dietetics disease driven by dysregulated Emergency emergency department Hospitalization Hypolipidemia ICU admission IL-10 IL-6 IL-8 immunothrombosis independent Inflammatory Inflammatory biomarker kidney LDL-C Lipid lipoprotein Lipoproteins multiorgan injury nutritional interventions observational study outcome Patient patients plasminogen Predictive presenting Primary outcome profile prospective observational study prothrombotic renal Secondary outcomes serum serum creatinine sick significantly lower thrombotic thrombotic microangiopathy USA were measured [DOI] 10.1016/j.dsx.2021.04.011 PMC 바로가기 [Article Type] Article
Differentially expressed immune response genes in COVID-19 patients based on disease severity질병 중증도에 따라 COVID-19 환자에서 차등적으로 발현되는 면역 반응 유전자Research Paper Published on 2021-04-152022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antiviral antiviral genes APOBEC3G Apolipoprotein Apolipoprotein B appear blood sample Blood samples case-control study catalytic changes in chemokine chemokines city collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 CXCL11 CXCL9 cytokine Cytokines death decreased expression disease Disease progression disease severity domain downregulated dysregulated immune response dysregulated immune responses enzyme expressed FADD Gene Expression genes encoding healthy control healthy controls healthy subject Host IFN IFNA1 IFNA2 IFNAR1 IL12A IL12B IL15 IL1B IL6 Illness severity immune response gene immune response genes immune responses induction IRF7 ISG15 microRNA mRNA MX1 Patient patients PCR progression Proinflammatory cytokine proinflammatory cytokines Protein recovered COVID-19 patient recruited respiratory RNA extraction SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Signaling significantly thought TLR8 TLR9 type I interferon underlie upregulated [DOI] 10.18632/aging.202877 PMC 바로가기 [Article Type] Research Paper
Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank영국 바이오뱅크에서 기준선 심장대사 프로파일 및 SARS-CoV-2 감염Research Article Published on 2021-04-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 바이오마커, [키워드] 95% confidence interval adjusted age alcohol ancestry ApoB Apolipoprotein Apolipoprotein B baseline BMI body mass body mass index cardiometabolic cardiometabolic risk factor characterized cholesterol coronavirus COVID-19 pandemic diabete diabetes Effect eliminated examined Factor HDL-C hemoglobin Hemoglobin A1c high density lipoprotein LDL-C Logistic regression low density lipoprotein objective Odds ratios pandemic participant positive profile profiles reduced Regulation remained respiratory respiratory infection responsible Result risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection Sepsis severe respiratory infection Sex significantly Study participants tested Triglyceride triglycerides Type type II diabete Type II Diabetes UK biobank UKB [DOI] 10.1371/journal.pone.0248602 PMC 바로가기 [Article Type] Research Article
Could COVID-19 anosmia and olfactory dysfunction trigger an increased risk of future dementia in patients with ApoE4?COVID-19 후각 기능 장애와 ApoE4 환자에서 향후 치매 위험이 증가할 수 있습니까?Article Published on 2021-02-012022-09-11 Journal: Medical Hypotheses [Category] 유전자 메커니즘, [키워드] acute illness acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alzheimer's disease Anosmia APOE4 carriers Apolipoprotein Apolipoprotein e approved association best Brain carrier Central nervous system Complication coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Dementia disease dysfunction e4 allele early stage early stages genetic risk factor Haplotype Hypothesis identify increased risk increasingly Infection involved knowledge Lewy Bodies) load mechanism Modification nasal neurodegenerative neurological Neuropsychiatric olfactory olfactory dysfunction olfactory nerve open Patient question reported respiratory risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus short duration speculation Stage subject Symptom Symptoms the strongest Therapies unique working hypothesis [DOI] 10.1016/j.mehy.2020.110479 PMC 바로가기 [Article Type] Article
Altered high-density lipoprotein composition and functions during severe COVID-19심각한 COVID-19 동안 변경된 고밀도 지단백질 구성 및 기능Article Published on 2021-01-272022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Admission affecting Alpha Altered amyloid A Analysis Anti-inflammatory antioxidant antitrypsin Apolipoprotein Apoptosis Biomarkers cadherin changes in conditions consequence controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Day Decreased Endothelial cell endothelial cells exposure to function HDL HDL-C HDLs healthy subjects high-density initial intensive care intensive care unit less lipid metabolism mass spectrometry pandemic Particle Patient patients worldwide permeability plasma Protective Protein proteome Proteomic analysis proteomics pulmonary damage reported SARS-CoV-2 serum amyloid severe COVID-19 severe COVID-19 patient severe COVID-19 patients Sex TNFα VE-cadherin viral infection was performed [DOI] 10.1038/s41598-021-81638-1 PMC 바로가기 [Article Type] Article