Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing VirusArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome animal models antiviral therapeutics antivirals biology of SARS-CoV-2 Care caused comparable contagious coronavirus coronavirus disease COVID-19 cultured cells demonstrated detect Express expresse expressing expression level facilitate feasibility fluorescent Genes hACE2 hamster Health human Angiotensin-converting enzyme in vitro In vitro assay in vivo infected cell Infection K18 knowledge limitation luciferase luciferase reporter gene luciferase reporter genes mCherry monitoring neutralizing antibody overcome pandemic pathogenicity Protein recombinant reporter responsible robust SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection transgenic mice Transmission Vaccine viral fitness viral infection virus wild-type [DOI] 10.1128/spectrum.02379-22 PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylationArticle Published on 2022-10-152022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] 치료제, [키워드] A549 cell activated Activation acute respiratory syndrome Affect and SARS-CoV-2 papain-like protease. contribute coronavirus coronavirus disease COVID-19 Curcumin decrease dose-dependent manner enzyme expression expression level function help immunomodulator Infection innate immune responses interferon interferon-stimulated gene Interferon-stimulated gene 15 kDa investigated ISG15 ISGylation kDa Modification monomer occur Papain-like protease pathogen Prevent Protein reduce SARS-CoV-2 severe COVID-19 Spread substrate suggested treated Treatment [DOI] 10.1016/j.bbrc.2022.08.003 PMC 바로가기
Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infectionArticle Published on 2022-10-032022-11-15 Journal: Virology Journal [Category] 치료제, [키워드] 25-hydroxyvitamin D age Analysis antiviral immune response association cholesterol control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patients determine differential expression disease downregulation enrolled Epigenetic erythrocyte sedimentation rate ESR evaluated expression level HDL healthy control high-density in both group indicated Infection LDL low-density Mild mild infection motif mRNA level multivariate logistic regression Patient patients PCR cycle polymerase chain Proteins qPCR reduction in required Severe COVID-19 Infection severe group Severe infection severe infections severity severity of COVID-19 significantly lower the mean threshold TRIM28 Tripartite Motif Tripartite motif containing 28. was used [DOI] 10.1186/s12985-022-01885-0 PMC 바로가기
Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axisArticle Published on 2022-10-012022-11-16 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Asymptomatic bioinformatics Bioinformatics analysis cDNA synthesis competing contagious correlation Correlation analysis CoV COVID-19 COVID-19 cytokine storm cytokine Cytokine storm expressed expression expression level expressions healthy controls hsa_circ_0004812 hsa-miR-1287-5p IL-6R IL6R in silico In-vitro Interaction material molecular mechanisms mononuclear cell negative control outcome pandemic Patient patients patients with asymptomatic PBMC Peripheral blood positive correlation positively correlated predicted promote qRT-PCR relative expression RIG-I RNA SARS-CoV-2 sponging effect. Symptom symptomatic the Coronaviridae the SARS-CoV-2 total RNA virus was performed [DOI] 10.1002/jcla.24666 PMC 바로가기
Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and TranscytosisArticle Published on 2022-10-012022-11-16 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 analyzed Caco-2 Caco-2 cell downregulation elevated endocytosis expression expression level expression of gene hypoxia hypoxic include increase in induction intestine involved LDL LDLR low-density LRP1 LRP4 LRP5 manuscript mechanism miRNA mRNA oxyquinoline receptor response RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 viral particles significant increase TFRC Transcriptome transcytosis Transport treated upregulation [DOI] 10.1134/S1607672922050118 PMC 바로가기
Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disordersArticle Published on 2022-09-292022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE1 ACE2 ACE2 expression ACE2 gene addition Ageusia Alu Analysis Angiotensin-converting enzyme Anosmia association Brain Cell cells cognitive Cognitive dysfunction Cohort consequence correlation COVID-19 disorder Effect evaluated expression expression level Factors gene expression level Genetic genetic association Health Hospitalized hospitalized patients human cell initial symptoms long-COVID long-COVID syndrome Loss of Smell loss of taste molecular nasopharyngeal negative New obligatory occur Olfactory epithelium outcomes penetration polymorphism prevalent priming protease Quantitative quantitative trait receptor Regression model Research Respiratory system RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Spread Symptom Symptoms tissue TMPRSS2 variable virus [DOI] 10.3389/fcimb.2022.905757 PMC 바로가기