Immune system dysfunction – Communicable Diseases Research

The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms

Review article

Published on 2022-10-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제,

An Overview of Systematic Reviews of the Role of Vitamin D on Inflammation in Patients with Diabetes and the Potentiality of Its Application on Diabetic Patients with COVID-19

당뇨병 환자의 염증에 대한 비타민 D의 역할에 대한 체계적인 검토에 대한 개요 및 Covid-19를 가진 당뇨병 환자에 대한 적용의 잠재력

Review

Published on 2022-03-062022-08-31
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, meta-analysis, SARS,

[키워드] acute respiratory syndrome application association cardiovascular disease chronic lung disease chronic renal disease Cochrane Library Comorbidities contribute coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 severity Cytokines deficiency diabete diabetes Diabetes Mellitus Effect Evidence Factor Health care health care systems high risk hyperglycemia hypertension immune immune response immune system Immune system dysfunction in some increase increased mortality Infection Infectious disease Inflammation Inflammatory marker inflammatory markers Inflammatory responses inflammatory state Lung disease malignancy modulator molecular basis mortality rate obesity outbreak overview pandemic Patient patients patients with comorbidity performed piece potentiality PubMed Central renal disease reported respiratory review role Severe acute respiratory syndrome severity subject systematic review systematic reviews systemic inflammatory response systemic inflammatory responses Vitamin D vitamin D deficiency Vitamin D supplementation vitamin D’ vitamin D’s with COVID-19 Wuhan
[DOI] 10.3390/ijms23052873 PMC 바로가기 [Article Type] Review

Role of senescence in the chronic health consequences of COVID-19

Review article

Published on 2022-03-012022-10-05
Journal: Translational research : the journal of laboratory [Category] SARS, 변종,

[키워드] A phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes acute COVID-19 alleviate alterations AMP-activated protein kinase AMPKAMP-activated protein kinase caloric restriction Cell cell removal cellular senescence chronic disease consequence contribute Coronavirus disease 2019 COVID-19 COVID-19 symptom COVID-19coronavirus disease 2019 COVID-FISA phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes CRcaloric restriction Defense deregulated dysfunction Epigenetic facility for geroscience analysis FGAFacility for Geroscience Analysis generate genomic greater Health ICUIntensive Care Unit IFintermittent fasting ill patients Immune system dysfunction increased risk indicated Infection infections Innate intensive care unit Intercellular communication interfere intermittent fasting Intervention Long-term care facility low-grade inflammation LTCFlong-term care facility mammalian target of rapamycin MCCmultiple chronic conditions MERS-CoVmiddle east respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus mitochondrial dysfunction Mortality mTORmammalian target of rapamycin Multimorbidity multiple chronic conditions NAD+nicotinamide adenine dinucleotide nicotinamide adenine dinucleotide nicotinamide mononucleotide nicotinamide riboside NMNnicotinamide mononucleotide NRnicotinamide riboside Older outcome PACSpostacute sequalae of SARS-CoV-2 infection PAMPspathogen-associated molecular profile factors pathogen-associated molecular profile factors Patient postacute sequalae of SARS-CoV-2 infection predictor reactive oxygen species risk risk factor role ROSreactive oxygen species SARS-CoV-1severe acute respiratory syndrome coronavirus 1 SARS-COV-2 infection SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARSSevere Acute Respiratory Syndrome SASPsenescence-associated secretory phenotype senescence-associated secretory phenotype senescent senescent cell Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 1 severe acute respiratory syndrome coronavirus 2 skilled nursing facility SNFskilled nursing facility susceptibility TGNtranslational geroscience network Translational Geroscience Network viral infection viral infections while WHOWorld Health Organization World Health Organization
[DOI] 10.1016/j.trsl.2021.10.003 [Article Type] Review article

The clinical spectrum of SARS-CoV-2 infection in Gaucher disease: Effect of both a pandemic and a rare disease that disrupts the immune system

Observational Study

Published on 2022-02-012022-10-05
Journal: Molecular genetics and metabolism [Category] COVID19(2023년), SARS, 임상,

Contributing factors common to COVID-19 and gastrointestinal cancer

Review

Published on 2022-01-122023-06-17
Journal: Oncology reports [Category] MERS, SARS,

[키워드] Colon cancer Contributing factors Coronavirus disease 2019 Esophageal Cancer gastrointestinal cancer Immune system dysfunction literature-related discovery severe acute respiratory syndrome coronavirus 2 stomach cancer
[DOI] 10.3892/or.2021.8227 PMC 바로가기 [Article Type] Review

Evidence for a connection between coronavirus disease-19 and exposure to radiofrequency radiation from wireless communications including 5G

Review Article

Published on 2021-09-292022-10-29
Journal: Journal of Clinical and Translational Research [Category] COVID-19,

[키워드] acute respiratory syndrome addition ambient amplify arrhythmia Autoimmunity cardiac disorders caused cellular changes in cofactor Community connection contribute contributed coronavirus coronavirus 2 Coronavirus disease-19 correlation COVID-19 COVID-19 pandemic detrimental disease Effect electromagnetic fields electromagnetic stress environmental factor epidemiological erythrocyte Evidence exacerbating examined free radical Health hemoglobin Immune system dysfunction Immunosuppression impair implementation infected with SARS-CoV-2 International investigated mechanism microwave millimeter wave organ outcome oxidative stress pandemic pathophysiology Patient peer-reviewed pro-inflammatory public health Radiation Radio Frequency radiofrequency reduce Relevance Replication Research resulting SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severity Spread statistical Vascular injury viral entry virus wireless Wuhan, China
PMC 바로가기 [Article Type] Review Article

Common contributing factors to COVID-19 and inflammatory bowel disease

COVID-19 Pandemic: Health impact and Novel research

Published on 2021-08-312022-10-04
Journal: Toxicology Reports [Category] 바이오마커, 유전자 메커니즘,

[키워드] Abstract acute respiratory syndrome approach biologic candidate Chronic diseases common Complication contribute Contributing factors coronavirus coronavirus disease COVID-19 Crohn’s disease Crohn’s disease demonstrated disease Diseases dysfunctional immune system event Factor Factors Government Health IBD identify immune dysfunction immune function immune response immune system Immune system dysfunction Impact impacted impair Infection Inflammatory bowel disease initial LRDI Multiple overlap overlapping pandemic psychosocial stressors representing Result SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome starting point Stressor toxic substance Treatment ulcerative colitis was used with COVID-19
[DOI] 10.1016/j.toxrep.2021.08.007 PMC 바로가기 [Article Type] COVID-19 Pandemic: Health impact and Novel research

Type-2 Diabetes as a Risk Factor for Severe COVID-19 Infection

Review

Published on 2021-06-032022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome Adipose tissue angiotensin-converting enzyme 2 bind caused complicate Complication contribute coronavirus coronavirus disease correlated COVID-19 COVID-19 disease COVID-19 progression COVID-19 severity diabete diabetes Diabetes Mellitus diabetic patient diabetic patients Effect expressed Factor Glucose glucose metabolism higher risk hyperglycemia immune response Immune system dysfunction impairment increased mortality infections Infectious disease metabolism notable organ outbreak pancreatic islets pathophysiology patients poor prognosis Protein receptors risk factor SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 severity spike glycoprotein suggested susceptible systemic inflammatory response tissue Type Vaccines
[DOI] 10.3390/microorganisms9061211 PMC 바로가기 [Article Type] Review

Type I and III interferon responses in SARS-CoV-2 infection

SARS-CoV-2 감염에서 I형 및 III형 인터페론 반응

Review

Published on 2021-05-062022-09-10
Journal: Experimental & Molecular Medicine [Category] SARS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity Antiviral effect antiviral effects block caused cellular response Cellular responses contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill critically ill patients Cytokines Defense element elements evade exacerbate explain expression Extensive Host host protein host proteins hyper-inflammation IFN IFN pathways IFNs immune cells immune system Immune system dysfunction IMPROVE infected cells Infection Infectious diseases Inflammation Inflammatory response Inflammatory responses influence inhibit innate cytokine innate cytokines interferon response interferons interferons (IFNs mechanism non-infected pandemic disease Patient progression researcher respiratory response responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Science severe acute respiratory syndrome Coronavirus severe COVID-19 Shin South Korea technology treatments for COVID-19 triggered Type type I type I and III IFNs type I and III interferons type I and type III interferons Type I IFN type I IFN responses type III interferon viruses
[DOI] 10.1038/s12276-021-00592-0 PMC 바로가기 [Article Type] Review

Interleukin-6 blocking agents for treating COVID-19: a living systematic review

COVID-19 치료를 위한 인터루킨-6 차단제: 살아있는 체계적인 검토

Meta-Analysis

Published on 2021-03-182022-09-11
Journal: The Cochrane database of systematic reviews [Category] 임상, 진단,

[키워드] 95% CI adverse event adverse events age all-cause mortality anti-IL6 approach articles available data average baseline benefit Bia blocking agent blocking agents Brazil can not Care certainty certainty of evidence China clinical Clinical improvement Cochrane COVID-19 Study Register collected data conducted coronavirus disease Coronavirus disease 2019 COVID-19 Critical Critical disease Data collection death defined disease disease severity Efficacy and safety eight evaluate evaluated Evidence excluded FIVE Follow-up France Health Organization heterogeneity hospital discharge identify IL-6 IL-6 blocking Immune system dysfunction immunosuppressive incidence Inclusion individual individual patient data meta-analyses Inflammation interleukin interleukin 6 interleukin 6 (IL-6 Intubated intubated patient intubated patients Italy male mechanical ventilation Meta-analysis methodology Mild moderate Mortality multicentre nine no increase not intubated organ support Other outcomes outcome outcomes oxygen participant Participants Patient patient data patients with COVID-19 peer-reviewed people with COVID-19 Placebo platform Platform trial progression proportion protocol randomised randomised controlled trial Randomised controlled trials ranged RCT RCTs reduce Registered registry reported risk of bia Safety sarilumab score searched Selection Serious Adverse Event Serious Adverse Events Seven severe coronavirus disease severity siltuximab standard care Standard of care subgroups of patient systematic review Tocilizumab Tolerance Treatment Trial trial participant trial participants trials unlikely USA WHO World Health Organization
[DOI] 10.1002/14651858.CD013881 PMC 바로가기 [Article Type] Meta-Analysis