Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human TranscriptomeArticle Published on 2021-07-272022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] addition Analysis bioinformatics Biological functions cleaved DNA effort endogenous function G-quadruplex Human human transcriptome immune pathway knowledge miRNA miRNA targeting nucleic acid post-transcriptional regulation Profiling provide Region regions Regulatory reveal RG4 RNA RNA G-quadruplex shown significantly Structure Transcriptome transcriptome-wide [DOI] 10.3390/ijms22158012 PMC 바로가기 [Article Type] Article
Adventitial Microcirculation Is a Major Target of SARS-CoV-2-Mediated Vascular InflammationCase Report Published on 2021-07-202022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] ACE2 receptor affected alteration analyses Analysis artery disease cardiovascular complication Case report changes controls coronavirus Coronavirus disease-19 Course COVID-19 cytoplasm disease Endothelial cell endothelial injury expressed functional histological IHC IL-6 immunohistochemistry infected with SARS-CoV-2 Infection Inflammation Inflammatory lower limb Major mechanism media Microcirculation miRNA mRNA occlusive oedema popliteal Protein SARS-CoV-2 significantly increased staining target TEM transmission electron microscopy Vascular damage was reduced [DOI] 10.3390/biom11071063 PMC 바로가기 [Article Type] Case Report
Identifying potential human and medicinal plant microRNAs against SARS-CoV-2 3′UTR region: A computational genomics assessmentArticle Published on 2021-07-192023-07-01 Journal: Computers in biology and medicine [Category] SARS, [키워드] antiviral defense computational genomics Conserved 3′UTR medicinal plants miRNA SARS-CoV-2 [DOI] 10.1016/j.compbiomed.2021.104662 PMC 바로가기 [Article Type] Article
MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant WomenSARS-CoV-2에 감염된 임산부의 혈장 및 태반에서 MiRNA 프로파일링Article Published on 2021-07-152022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] absence analysed anatomical Asymptomatic biopsies biopsy Blood characteristic chemokines clinical symptom Clinical symptoms collected Combination COVID-19 ELISA expression Factor Gene Expression immune reaction immune response Infection investigated microRNA MicroRNAs miRNA miRNA expression mRNA Pathologies Placenta placental positive potential therapeutic target pregnant women Profiling representing SARS-CoV-2 SARS-COV-2 infection significantly transcriptomic profile Transmission uninfected vertical transmission Viral viral infections [DOI] 10.3390/cells10071788 PMC 바로가기 [Article Type] Article
The relative expression of miR-31, miR-29, miR-126, and miR-17 and their mRNA targets in the serum of COVID-19 patients with different grades during hospitalizationResearch Published on 2021-07-132022-10-31 Journal: European Journal of Medical Research [Category] COVID-19, SARS, [키워드] Blood blood sample CAMSAP1 COL5A3 correlation COVID-19 COVID-19 patient COVID-19 patients cross-sectional Diagnosis DICER1 disease evaluate evaluated expression health center help Hospitalization Inflammatory investigated Iran Medical Sciences miRNA miRNAs mRNA Prognosis Registered relative expression respond Result returned selected serum serum sample significantly significantly increased target Tehran Treatment university Yazd ZMYM5 [DOI] 10.1186/s40001-021-00544-4 PMC 바로가기 [Article Type] Research
Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host CellsSARS-CoV-2의 뉴클레오캡시드 유전자에 의해 암호화된 바이러스성 MicroRNA는 감염 중에 감지되고 숙주 세포에서 대사 경로를 표적화합니다Communication Published on 2021-07-122022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] absence association Biomarker Biosynthesis Calu-3 cell lines cellular interactions cellular metabolism conserved COVID-19 COVID-19 patients Critical deep sequencing disease disease pathogenesis DNA and RNA dysregulation effective expression functional Gene Expression host target genes identify immune dysregulation in silico analysis induce infective initial screening mapped mechanism metabolic metabolism microRNA MicroRNAs miRNA miRNAs N gene Pathogenesis pathogenesis of COVID-19 pathophysiology pathway Prevalence RNA sequence RNA viruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 strains selected shown Support target targeting the SARS-CoV-2 genome Therapeutic strategies therapeutic strategy Treatment v-miRNA v-miRNAs Vero E6 Viral Viral load viral miRNAs virus virus production viruses [DOI] 10.3390/cells10071762 PMC 바로가기 [Article Type] Communication
Long and short non-coding RNA and radiation response: a reviewReview article Published on 2021-07-012022-10-05 Journal: Translational research : the journal of laboratory [Category] 비임상, [키워드] alteration anti-sense oligonucleotides arising ASOanti-sense oligonucleotides binding biofluids Biomarker CADcoronary artery disease Cancer Cell cellular processe cellular stress response changes in circRNAcircular RNA circular RNA Coronary artery disease DCAdicentric chromosome assay diabete diagnostic dicentric chromosome assay disease Disease progression DNA Effect EMTepithelial-to-mesenchymal transition epithelial-to-mesenchymal transition evaluate examined expression level expression profile form Future gray (unit) Gygray (unit) interactions introduced invasive ionizing radiation IRionizing radiation lncRNA lncRNAlong noncoding RNA Long long noncoding RNA Messenger RNA microRNA miRNA miRNAmicroRNA modulate modulation mRNA mRNAMessenger RNA mRNAs ncRNA ncRNAnoncoding RNA ncRNAs non-coding RNA Non-small cell lung cancer noncoding RNA NSCLCnon-small cell lung cancer oxidative stress PBMCperipheral blood mononuclear cells Peripheral blood mononuclear cells piRNApiwi-interacting RNA piwi-interacting RNA prognostic biomarker Proteins Radiation radiation exposure Radiotherapy reactive oxygen species regulate reported Research RNA RNA expression RNA interference RNAiRNA interference ROSreactive oxygen species serum short hairpin RNA shown shRNAshort hairpin RNA siRNAsmall interfering RNA Small interfering RNA small nuclear RNA small nucleolar RNA snoRNAsmall nucleolar RNA snRNAsmall nuclear RNA stability Stress TBItotal body irradiation therapeutic use thought total body irradiation transfer RNA tRNAtransfer RNA untranslated region UTRuntranslated region [DOI] 10.1016/j.trsl.2021.02.005 [Article Type] Review article
First comprehensive computational analysis of functional consequences of TMPRSS2 SNPs in susceptibility to SARS-CoV-2 among different populations다양한 인구 집단에서 SARS-CoV-2에 대한 감수성에서 TMPRSS2 SNP의 기능적 결과에 대한 최초의 포괄적인 계산 분석Article Published on 2021-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] 유전자 메커니즘, [키워드] Affect affected analyzed Antiviral antiviral drugs appearance Asian Asians Cell computational analysis current dbSNP de novo Donor donor site Effect ENCODE enhancer Ensembl Epigenetic ExPASY expression profile Frequency functional functional consequence Hypothesis in silico investigated KEGG mechanism miRNA miRNA profile miRNA profiles miRNAs Mortality motifs non-coding RNA Non-coding RNAs nucleotide PolyPhen-2 Population populations post-translational modification predict Protein protein folding PSIPRED retrieved SARS-CoV-2 SARS-CoV-2 cell SARS-CoV2 secondary structure Serine SIFT Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs splicing susceptibility susceptible therapeutic TMPRSS2 transmembrane serine protease were used [DOI] 10.1080/07391102.2020.1767690 PMC 바로가기 [Article Type] Article
The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review인간 세포에서 SARS-CoV-2 감염을 조절하는 microRNA의 역할: 체계적인 검토Article Published on 2021-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] ACE2 addition Analysis applied article association caused cell interactions cleavage Complex network Complex networks COVID-19 COVID-19 patients Critical database disease eligibility criteria Evidence expression level expression levels function Gene Expression gene target Genes Genome Genome sequencing highlight host cells host genes host miRNA host miRNAs host responses human disease human infection in silico independent infected cell Infection infections Interaction microRNA MicroRNAs miRNA miRNAs modulating MOST Mutation Pathologies predicted Prospective PROSPERO Proteins protocol provide Registered regulate reported Research review SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates searched selected Sequencing specimen suggested systematic review therapeutic target therapeutic targets TMPRSS2 translation viral genome virus virus infection [DOI] 10.1016/j.meegid.2021.104832 PMC 바로가기 [Article Type] Article
In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patientsResearch Paper Published on 2021-06-302022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adenocarcinoma Analysis cancers cause CD8 Cell Comorbidity component comprehensive analysis contagious coronavirus coronavirus disease COVID-19 COVID-19 patients Endothelial cell event expressed facilitate human tissue ICU identify immune infiltration infiltration information lung lung cancer lung cancer patient Macrophage miRNA negative correlation Neuropilin-1 NRP1 oncogenic pathogenic performed Peripheral blood potential therapeutic target RNA-seq data SARS-CoV-2 SARS-COV-2 infection significantly Squamous cell carcinoma survival T cell target TMPRSS2 TMPRSS2 level Treatment worse prognosis [DOI] 10.18632/aging.203159 PMC 바로가기 [Article Type] Research Paper