mononuclear cell – Page 15 – Communicable Diseases Research

Study of the Plasma and Buffy Coat in Patients with SARS-CoV-2 Infection—A Preliminary Report

Article

Published on 2021-06-252022-10-28
Journal: Pathogens [Category] COVID-19,

Integrated analysis of multimodal single-cell data

Resource

Published on 2021-06-242022-10-31
Journal: Cell [Category] COVID-19, MERS, SARS,

Chronic Immune Activation and CD4 + T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy

Immunology

Published on 2021-06-172022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] accompanied addition Africa African American anti-SARS-CoV-2 vaccine CCR5 CD4 CD8 cellular activation characterized chronic chronic immune activation COVID-19 cytokine driving Effectiveness environmental factor European Europeans Evidence Helminths HIV-1 HIV-negative HLA-DR hyporesponsiveness IL-10 immune immune activation Immune profile in vitro individual Infant infected individuals Infection innate cytokine less marker mechanisms memory cell mononuclear cell naïve North populations reduced required responsible SARS-CoV-2 secrete South T cell T cell depletion TNF-α Vaccine Vaccines
[DOI] 10.3389/fimmu.2021.693269 PMC 바로가기 [Article Type] Immunology

Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients

강력한 SARS-CoV-2-특이적 T 세포 면역 및 낮은 아나필라톡신 수치는 COVID-19 환자의 경증 질병 진행과 상관관계가 있습니다

Immunology

Published on 2021-06-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법,

[키워드] addition analyzed anaphylatoxin anaphylatoxin C3a Antibody titer Antibody titers Blood C5a caused CD4 CD8 cellular characterized clearance Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient disease severity elevated ELISA ELISPOT ELISpot assay evaluated flow cytometry healthy individual highest humoral immune response IFNγ IgG immune complex immune responses immunodominant indicate infected individuals Level Lymphocytes lymphopenia Mild mild infections mononuclear cell mononuclear cells Mortality neutralization ability neutralizing Abs Neutralizing activity nucleocapsid Patient patients peptide peptide pool peripheral Peripheral blood Peripheral blood mononuclear cells potent reduced respiratory Respiratory system robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-infected individuals SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe disease progression significantly specific antibodies Spike proteins T cell T cell immunity T cell response T cell responses T cells T lymphocyte Viral viral infection viral infections
[DOI] 10.3389/fimmu.2021.684014 PMC 바로가기 [Article Type] Immunology

Mucosal-associated invariant T cell responses differ by sex in COVID-19

COVID-19에서 점막 관련 불변 T 세포 반응은 성별에 따라 다릅니다

Article

Published on 2021-06-112022-09-11
Journal: Med (New York, N.Y.) [Category] MERS, 유전자 메커니즘, 임상, 진단,

[키워드] aerosol Affair airway Apoptosis biosafety level BSL-2 BSL-3 carried Cell cells from male circulating construction content contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sample COVID-19 samples COVID-19 susceptibility DARPA dataset Duke early infection female females flow cytometry gene signature healthy control Hospitalized IL-7 immune response immune responses immunologically individual Innate immunity integration level 2 management mechanism monocyte mononuclear cell mononuclear cells outcomes Peripheral blood Peripheral blood mononuclear cells pro-apoptotic processed Protective Quality Quality assurance reduced reduction Regional Biocontainment Laboratory responsibility SARS-CoV-2 Sex sexual dimorphism sexual dimorphisms Single-cell RNA sequencing Support supported System T cell response tissue uninfected veteran Virology
[DOI] 10.1016/j.medj.2021.04.008 PMC 바로가기 [Article Type] Article

Identification of Lung and Blood Microbiota Implicated in COVID-19 Prognosis

Article

Published on 2021-06-102022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2

어린 유아는 SARS-CoV-2에 대한 강력한 기능적 항체 반응과 억제된 IFN-γ 생산을 나타냅니다.

Comparative Study

Published on 2021-06-092022-09-12
Journal: Cell Reports Medicine [Category] MERS, 진단,

Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workers

SARS-COV-2 SEROCONVERSION (PASS) 연구의 전향 적 평가 : 의료 근로자의 SARS-COV-2 감염 및 예방 접종에 대한 관찰 코호트 연구

Study Protocol

Published on 2021-06-092022-09-01
Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단,

[키워드] Affect Analysis Anti-spike antibody assessment Asymptomatic baseline clinical response Cohort Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 CoV covariates COVID-19 COVID-19 disease COVID-19 disease course cross-reactivity cytokine production determine develop disease symptoms evaluate Frequency glycoprotein HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HCWs healthcare healthcare worker HKU1 human coronavirus IgG antibodies IgM and IgG immune response immune responses Immune-response immunological individual Infection intensity Killer cell magnitude mononuclear cell natural natural killer cell NL63 number of infected Observational cohort study OC43 pandemic coronavirus participant pauci-symptomatic PBMCs peptide peptide pool performed Peripheral blood Peripheral blood mononuclear cells positive Prospective Prospective Study questionnaire receive respiratory Respiratory disease Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 PCR testing SARS-CoV-2 vaccination SARS-CoV-2 vaccine seroconvert serology analysis severe respiratory illness severity Spike proteins supplementary material Symptom T cell T cell activation T cell response T cell responses tested the SARS-CoV-2 the spike protein vaccination Vaccine viral respiratory with COVID-19
[DOI] 10.1186/s12879-021-06233-1 PMC 바로가기 [Article Type] Study Protocol

Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control

Article

Published on 2021-06-042022-10-04
Journal: Scientific Reports [Category] 바이오마커,

[키워드] ABCA1 ANLN approach Asthma asthma patient asthmatic asthmatic patient Asthmatic patients Biomarker Blood Bronchial epithelium Cell complex interplay Comprehensive derangement deviate downregulated driver examined Factor fibroblast fibroblasts Gene Expression GPRC5A healthy help heterogeneity homeostasis identify immunology in vitro KRT8 lung marker MKI67 molecular basis Molecular biology mononuclear cell NEK2 pathway Patient PBMC Peripheral blood phenotype progression proliferation qPCR recruited representing RRM2 SERPINE1 SFN Systems biology Th2 therapy tissue tissue remodeling TOP2A transcriptomic data upregulated validation were used wheeze
[DOI] 10.1038/s41598-021-91087-5 PMC 바로가기 [Article Type] Article

Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19

말초 면역 세포의 단일 세포 후성유전체 환경은 COVID-19에서 회복 중인 개인의 훈련된 면역 확립을 보여줍니다

Article

Published on 2021-06-012022-09-11
Journal: Nature cell biology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법,

[키워드] accelerated activated acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis antibody asymptomatic infection B cell B-cell cause CD14 CD16 CD8 chromatin collected coronavirus coronavirus 2 COVID-19 death developmental differentiation epigenomic exhibited expansion healthy donors highlighting immature Immune cell immune cells immune response immune responses Immunity Immunological memory individual individuals Infection IRF1 Lineage Memory cells monocyte Monocytes mononuclear cell performed Peripheral blood Peripheral blood mononuclear cells Plasma cells profile promote reported reveal SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe complication severe complications single-cell T cell T cells
[DOI] 10.1038/s41556-021-00690-1 PMC 바로가기 [Article Type] Article