Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development effortsSARS-COV-2와 싸우기 위해자가 포식 활용 : 최근 약물 개발 노력의 고려에 대한 업데이트Review Published on 2022-02-012022-08-31 Journal: Journal of cellular biochemistry [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 autophagy contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 therapeutics drug Drug repurposing effort Health Organization immune system Infection life cycle pandemic Pharmacology potentially life-threatening respiratory SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 temper the SARS-CoV-2 therapeutic effect Treatment strategies virophagy World Health Organization [DOI] 10.1002/jcb.30166 PMC 바로가기 [Article Type] Review
Covid-19 and Artificial Intelligence: Genome sequencing, drug development and vaccine discovery코비드-19와 인공 지능: 게놈 시퀀싱, 약물 개발 및 백신 발견Review Published on 2022-02-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] abacavir agility Almitrine applied approval article artificial artificial intelligence Atazanavir bioinformatics Care challenges clinical trial clinical trials collecting data COVID-19 COVID-19 pandemic COVID-19 virus databases deep learning difficulty dolutegravir drug Drug development Drug repurposing drugs efavirenz Genome sequencing genomic genomic sequence genomic sequencing Google Google Scholar growth Health Health care help hydrochloride inhibitor internal and external interpretability machine learning Messenger RNA mesylate Olaparib omicron PARP1 provide recognize Remdesivir Ritonavir Roflumilast SARS- CoV-2 SARS-CoV-2 proteome sequence Sequencing strain structural proteins therapeutic agent therapeutic effect Vaccine Vaccines variants variants of concern Viral vector vaccines VoC was done [DOI] 10.1016/j.jiph.2022.01.011 PMC 바로가기 [Article Type] Review
Potential antiviral properties of antiplatelet agents against SARS-CoV-2 infection: an in silico perspectiveArticle Published on 2022-02-012023-07-06 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID19(2023년), [키워드] antiplatelet COVID-19 Drug repurposing MPro SARS-CoV-2 spike [DOI] 10.1007/s11239-021-02558-5 PMC 바로가기
Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2: A Combined in silico and in vitro StudyArticle Published on 2022-02-012023-07-06 Journal: Molecular informatics [Category] COVID19(2023년), [키워드] COVID19 docking Drug repurposing main protease MD simulations SARS-CoV-2 Spike/ACE-2 Virtual screening [DOI] 10.1002/minf.202100062 PMC 바로가기
Discovery and repurposing of artemisinin아르테미시닌의 발견과 용도 변경Review Published on 2022-02-012022-09-11 Journal: Frontiers of medicine [Category] Coronavirus, 신약개발, [키워드] Artemisinin Cancer China Chinese COVID-19 derivative Diseases drug Drug repurposing drug-resistant Health Organization healthcare help high potency implication Infectious disease Inflammation initial malaria paradigm shift parasite starting point TCM Toxicity Traditional Chinese medicine treat Treatment World Health Organization [DOI] 10.1007/s11684-021-0898-6 PMC 바로가기 [Article Type] Review
Identification of SARS-CoV-2 Papain-like Protease (PLpro) Inhibitors Using Combined Computational ApproachArticle Published on 2022-02-012023-07-08 Journal: ChemistryOpen [Category] COVID19(2023년), [키워드] Drug repurposing ISM molecular docking Papain-like protease SARS-CoV-2 [DOI] 10.1002/open.202100248 PMC 바로가기
Integrating heterogeneous data to facilitate COVID-19 drug repurposing이종 데이터를 통합하여 CovID-19 약물 용도를 용이하게합니다Review Published on 2022-02-012022-08-31 Journal: Drug discovery today [Category] 신약개발, 임상, 치료제, [키워드] addition alternative candidate clinical trial clinical trials COVID-19 COVID-19 pandemic COVID-19 symptom COVID-19 symptoms data-driven Data-driven approaches disease drug Drug repurposing drugs facilitate Final FIVE heterogeneous information Intersection list SARS-CoV-2 Support Symptom therapeutic potential time-consuming treat [DOI] 10.1016/j.drudis.2021.10.002 PMC 바로가기 [Article Type] Review
The anti-HCV, Sofosbuvir, versus the anti-EBOV Remdesivir against SARS-CoV-2 RNA dependent RNA polymerase in silicoSARS-CoV-2 RNA 의존성 RNA 중합효소에 대한 항-HCV, Sofosbuvir 대 항-EBOV Remdesivir in silicoArticle Published on 2022-02-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active form affecting Anti-HCV antiviral drugs approved binding binding affinity binding energy binding mechanism clinically comparable complexes Control coronavirus diseases Coronaviruses COVID-19 disease docked docking drug Drug repurposing Effectiveness Efficacy FDA HCV Health help in silico inhibitor Interaction Ligand limit molecular docking molecular dynamics Molecular dynamics simulation Nsp12 nsp12 protein nucleotide polymerases positive control Protein RdRP Remdesivir reported RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA sofosbuvir target tested the binding affinity the SARS-CoV-2 therapeutic target three-dimensional structure used to evaluate Viral protein [DOI] 10.1007/s11030-020-10178-z PMC 바로가기 [Article Type] Article
Naltrexone a potential therapeutic candidate for COVID-19Article Published on 2022-02-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 approved binding bioinformatics clinical coronavirus 2 Coronavirus infection COVID-19 COVID-19 patients Cytokines storm disrupt docking downstream Drug repurposing global pandemic glycoprotein host cells host receptor Hyperinflammatory induce inhibit inhibitor Interaction interfere Like lung tissue macrophage cell molecular molecular docking multiple organ failure naltrexone other coronaviruses Phosphorylation positively correlated pro-inflammatory cytokine pro-inflammatory cytokine release pro-inflammatory cytokine storm Protein RBD reported required respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection spike structural bioinformatics suppresse suppressed surface Spike tested the SARS-CoV-2 therapeutic therapy Toxicity Treatment viral entry viral infectivity viral replication virus load [DOI] 10.1080/07391102.2020.1820379 PMC 바로가기 [Article Type] Article
Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of actionSARS-COV-2 감염의 치료를위한 약물 용도 : 작용 메커니즘에 대한 전산 설계 통찰력Article Published on 2022-02-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료법, 치료제, [키워드] accelerate binding site Broad Institute caused ChEMBL Compound Computational drug Coronavirus infection COVID-19 COVID-19 pandemic database deaths determine develop drug Drug development Drug repurposing feature Features health emergency help human population identify in vitro in vitro data in vivo inhibit inhibitors inhibitors of SARS-CoV-2 Interaction life Ligand mechanism molecules negatively affected non-structural proteins Novel coronavirus Novel coronavirus infection nucleocapsid nucleocapsid protein pharmacophore predicted progressed Protein Protein binding Protein target protein targets repurposing Research SARS-CoV-2 SARS-CoV-2 genome screened the SARS-CoV-2 genome therapeutic intervention therapeutic interventions Treatment Viral Viral protein Viral proteins Virtual screening virus Visualisation was used [DOI] 10.1080/07391102.2020.1825232 PMC 바로가기 [Article Type] Article