A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivoArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome Administered Antiviral antiviral activity association atomic Atomic force microscopy banana binding binding site cellular component concentrations conserved coronavirus effective experiment glycan healthy high affinity high-mannose human cells identify in vivo inhibit intranasally intraperitoneally lack lectin MERS-CoV MERS-CoV infection Microscopy Middle East modeling omicron PROTECT recognize resistant mutants respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike single-molecule force spectroscopy spike spike trimer target the SARS-CoV-2 Treatment Viral protein virus entry [DOI] 10.1016/j.xcrm.2022.100774 PMC 바로가기
SARS-CoV-2 specific antibody trajectories in mothers and infants over two months following maternal infectionArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] Adults anti-SARS-CoV-2 antibody Blood Breastfeeding children close contact collected Comparative concentrations conducted control group COVID COVID-19 COVID-19 infection dried blood spot IgA IgG incidence of COVID-19 infancy Infant Infants infected with SARS-CoV-2 Infection infection risk intensive care likelihood mother Neonatal Older outcome PCR positivity pediatric positive Probability reported Research Result returned risk S-RBD SARS-CoV-2 SARS-COV-2 infection Support Symptom tested the mean trajectory [DOI] 10.3389/fimmu.2022.1015002 PMC 바로가기
Genetic Load of SARS-CoV-2 in Aerosols Collected in Operating TheatersArticle Published on 2022-10-112022-11-15 Journal: Applied and Environmental Microbiology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] aerosol aerosol-generating procedure analyzed Care collected Concentration concentrations conducted coronavirus COVID-19 COVID-19 pandemic COVID-19 test Critical equipment evaluate genetic material Health Health care worker health care workers healthcare highlight implementation infected with SARS-CoV-2 information load measure N1 and N2 Operating room operating theaters outbreak Patient patients Potential presenting Prevent preventative measure preventive measure Protective protocol regions risk of COVID-19 RNA RT-qPCR Sample SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 RNA SARS-CoV-2 virion Surveillance the patient the SARS-CoV-2 Transmission Viral load virus [DOI] 10.1128/aem.01297-22 PMC 바로가기
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysisResearch article Published on 2022-10-012022-10-05 Journal: Journal of pharmacological sciences [Category] 바이오마커, 진단, [키워드] Analysis analyzed Biomarker characterization Concentration concentrations coronavirus disease COVID-19 COVID-19 severity diagnostic disease severity effective high mortality management moderate disease pandemic pathophysiology Patient patients with COVID-19 Prognosis prognostic biomarker Serotonin serum severe COVID-19 severe disease severity and prognosis significantly lower worsened [DOI] 10.1016/j.jphs.2022.06.005 [Article Type] Research article
Diagnostic performance of the SARS-CoV-2 S1RBD IgG ELISA (ImmunoDiagnostics) for the quantitative detection of SARS-CoV-2 antibodies on dried blood spotsArticle Published on 2022-10-012022-11-15 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] absence analysed Anti-spike antibodies Antibody detection Blood Concentration concentrations correlated correlation cut-off cut-off value dried blood spot Dried blood spots (DBS) ELISA ELISA kit enzyme-linked immunosorbent assay Enzyme-linked immunosorbent assay (ELISA) Euroimmun evaluate Follow-up humoral IgG IgG ELISA immune responses increasingly International Units/mL MONITOR Pearson correlation performed quantification Quantitative reference method SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 S1 SARS-CoV-2 surveillance sensitivity Sensitivity and specificity serology Serosurveillance serum serum antibody serum samples specificity spot statistical the SARS-CoV-2 vaccination vaccine responses was used [DOI] 10.1016/j.jcv.2022.105270 PMC 바로가기
Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart TissuesArticle Published on 2022-10-012022-11-15 Journal: Advanced Science [Category] 신약개발, 치료제, [키워드] antiviral drugs approved drugs ATP2A2 cardiotoxic effect Cardiotoxicity cell death Clinical data clinical trial clinically concentrations contractile Coronavirus disease 2019 COVID-19 demonstrated drug drug candidate drug treatments dysregulation effective engineered heart tissue evaluate expression of gene fumarate handling HCN4 heart heart tissue High Throughput Screening Human human pluripotent stem cell-derived cardiomyocytes induced ion homeostasis limit MYH6 Patient powerful tool regulate Remdesivir Repurposed drug repurposed drugs for COVID-19. reveal Ritonavir RNA-seq analysis significantly Spread STEM therapy TNNT2 [DOI] 10.1002/advs.202203388 PMC 바로가기
Evaluation of filter paper to transport oro/nasopharyngeal samples to detect SARS-CoV-2 by RT-qPCRRT-qPCR에 의한 SARS-CoV-2 검출을 위한 구강/비인두 샘플 수송을 위한 여과지의 평가Article Published on 2022-10-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] addition amplification approach carried clinical sample concentrations detect evaluate evaluated false-negative false-negative results feasible Filter Filter Paper generate impregnation Inconclusive Laboratory N1 and N2 positive result presenting qPCR reference method resource RNA extraction RT-qPCR SARS-CoV-2 SARS-CoV-2 detection specimen target Transport transportation Viral load [DOI] 10.1016/j.jviromet.2022.114587 PMC 바로가기 [Article Type] Article
Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profileArticle Published on 2022-09-272022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] 229E antibodies antibody Barcelona Blood blood sample C-terminus cause chemokine collected Concentration concentrations COVID-19 cytokine level cytokine levels cytokine profile cytokine response Cytokines distress domain EGF FGF full-length growth factor higher risk HKU1 human coronavirus Humoral response IFN-α IgA level IgG IgM IL-15 IL-17 IL-7 immune response immunological increased risk induce Infection Inflammatory investigated male Maternal maternal and neonatal immunity mother Neonatal Newborn NL63 non-infected nucleocapsid OC43 outcome outcomes positive positive correlation positive for rRT-PCR Pregnancy pregnant women Preterm birth profiles Questionnaires RANTES recruited reduction robust rRT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs serology severe COVID-19 Spain Swab Symptom symptomatic tested transfer transplacental transfer. Vaccines variables was increased were infected were recorded women [DOI] 10.3389/fimmu.2022.999136 PMC 바로가기
Cross-GWAS coherence test at the gene and pathway levelArticle Published on 2022-09-262022-11-16 Journal: PLoS Computational Biology [Category] 변종, [키워드] 25OHD affecting Algorithm analyses Analysis approach association bone structure calculated Cell Chemokine receptor coefficients concentrations correlated cumulative datapoint detect distribution Effect effect size expression genetic link Genetic variant Genome-wide association study GWAS immune response independent integrin linear combination medication pathway Pathways positive Precision rheumatoid arthritis serum calcium severity of COVID-19 structures traits utility [DOI] 10.1371/journal.pcbi.1010517 PMC 바로가기
Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cellsArticle Published on 2022-09-162022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] ACE2-positive cell addition ADE ADE activity adverse effect anti-SARS-CoV-2 antibody Antibody-dependent enhancement Antisera approved caused collected concentrations COVID-19 pandemic examined exhibited FcR in vivo individual Infection inoculated mAb mAbs monoclonal mRNA vaccines Neutralizing Neutralizing activity omicron S-protein SARS-CoV-2 spike protein sera therapeutic therapeutic effect [DOI] 10.1038/s41598-022-19993-w PMC 바로가기