Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking분자 도킹을 사용한 COVID-19 RNA 의존성 RNA 중합효소에 대한 리포펩티드Article Published on 2021-12-012022-09-11 Journal: Biomedical journal [Category] SARS, 변종, 치료제, [키워드] affinities Amino acid amino acids Analysis approach approaches binding Biological functions caused complex conserved Coronaviral coronavirus disease Coronavirus disease 2019 COVID-19 disease drug drug candidate FDA-approved drug fingers free energy hydrogen hydrogen bonds hydrophobic hydrophobic interactions Interaction iron lipopeptide molecular docking Mutation Nsp12 pandemic predict Remdesivir Replication responsible RNA-dependent RNA polymerase Salt Bridge SARS-CoV-2 Seven Spread the disease thumb Transcription Treatment Vaccine virus was used with COVID-19 [DOI] 10.1016/j.bj.2021.11.010 PMC 바로가기 [Article Type] Article
The glycosylation in SARS-CoV-2 and its receptor ACE2SARS-CoV-2 및 그 수용체 ACE2의 글리코실화Review Published on 2021-11-152022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved binding biological function Biological functions Biological techniques caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy death electron microscopy ENCODE envelope glycosylated glycosylation Host individual Infectious disease Infectious diseases membrane methodology Microscopy ORF3a Pathogenesis penetration Proteins receptor ACE2 respiratory responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus substrates the SARS-CoV-2 genome therapeutic Topology variants Viral [DOI] 10.1038/s41392-021-00809-8 PMC 바로가기 [Article Type] Review
Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENVCOVID-19 및 DENGUE 동시 감염에 대한 케르세틴: SARS-CoV-2 및 DENV에 의해 유발되는 중요한 숙주 신호 경로를 표적으로 하는 잠재적 치료 전략Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] alleviate Analysis bioinformatics biological function Biological functions CCL-2 Clinical characteristics clinical consequence clinical consequences Co-infection Computational biology COVID-19 Critical current CXCL8 Cytokines cytokines release Dengue drug drug trial evaluate Evidence excessive immune response functional Host IL-17 immune responses indicated Inflammation inflammatory pathway inhibit Intervention mechanism mechanisms NF-κB overlapping pathway patients pharmacological pharmacological target potential molecular PPI protein-protein interaction public health quercetin SARS-CoV-2 shown signaling pathways target targets therapeutic therapeutic strategy TNFα Toll-like receptor toll-like receptor signaling Treatment treatment of COVID-19 triggered upstream virus [DOI] 10.1093/bib/bbab199 PMC 바로가기 [Article Type] Article
Phillyrin for COVID-19 and Influenza Co-infection: A Potential Therapeutic Strategy Targeting Host Based on Bioinformatics AnalysisPharmacology Published on 2021-11-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] AKT anti-inflammatory effect bioinformatics Bioinformatics analysis Biological functions biological pathway biological processes Co-infection COVID-19 drug trial expected Genes HIF-1 IL-2 immune indicated Influenza inhibit KEGG Kyoto mechanism MMP9 network pharmacology pathway Pathways pharmacological phillyrin PI3K-Akt signaling Potential PPI previous study Protein–protein interaction Regulation Regulatory Replication risk shown signaling pathway Strategy T cell receptor target targeting targets therapeutic therapeutic potential Treatment upstream VEGFA viruses [DOI] 10.3389/fphar.2021.754241 PMC 바로가기 [Article Type] Pharmacology
Fluorescent glycan fingerprinting of SARS2 spike proteinsArticle Published on 2021-10-142022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] Analysis Biological functions COVID-19 pandemic digested enzyme fluorescent gel electrophoresis glycan glycobiology Glycoconjugates glycoprotein glycosylation identify identity Impact labeling lack Novel coronavirus peptide post-translational modification Protein released S protein SARS2 SDS-PAGE separated sialic acid Spike protein the S protein trypsin [DOI] 10.1038/s41598-021-98919-4 PMC 바로가기 [Article Type] Article
Emerging therapeutic opportunities for integrin inhibitors Reviews Published on 2021-09-172022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, [키워드] Biological functions bowel Cancer cardiovascular diseases Cell clinical development clinical trials clinically disease Diseases drug Drug discovery Inflammatory inhibitor integrin Integrins investigated New Osteoporosis pharmacological Protein pulmonary fibrosis Research review steatohepatitis therapeutic Treatment [DOI] 10.1038/s41573-021-00284-4 [Article Type] Reviews
Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses통합 생물정보학 분석을 기반으로 한 COVID-19 및 뎅기열 숙주 인자 상호작용 네트워크 식별Immunology Published on 2021-07-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] addition Analysis bioinformatics bioinformatics analyses Biological functions biological process build candidate drug candidate drugs categories CCL2 CCL4 Clinical practice Co-infection conducted contribute coronavirus disease Coronavirus disease 2019 COVID-19 Dengue Dexamethasone drug dysregulated enrichment analysis expressed Factor Genes Genistein Health crisis Host host factor interaction networks ICAM-1 identification identify IL-1 Interaction international public health Intervention lung management mechanism molecular Molecular Complex Detection network outbreak pathologic pathway performed potential therapeutic agents potential therapeutic target potential therapeutic targets PPI probe protein-protein interaction provide raised receptor signaling respiratory Respiratory disease Result resveratrol screened signaling pathway signaling pathways significant effect significant pathways target therapeutic agents TNF-α Toll-like receptor Treatment upregulated gene upregulated genes [DOI] 10.3389/fimmu.2021.707287 PMC 바로가기 [Article Type] Immunology
Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human TranscriptomeArticle Published on 2021-07-272022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] addition Analysis bioinformatics Biological functions cleaved DNA effort endogenous function G-quadruplex Human human transcriptome immune pathway knowledge miRNA miRNA targeting nucleic acid post-transcriptional regulation Profiling provide Region regions Regulatory reveal RG4 RNA RNA G-quadruplex shown significantly Structure Transcriptome transcriptome-wide [DOI] 10.3390/ijms22158012 PMC 바로가기 [Article Type] Article
Exosome-Based Vaccines: History, Current State, and Clinical Trials엑소좀 기반 백신: 역사, 현재 상태 및 임상 시험Review Published on 2021-07-142022-09-11 Journal: Frontiers in Immunology [Category] SARS, 임상, [키워드] Biological functions Cancer cancer cell Cancer cells cell proliferation cell type cell types clinical clinical trial conducted coronavirus coronavirus disease current dendritic cell dendritic cells Diseases Evidence EVs example Exosome Exosomes Extracellular vesicles extracellular vesicles (EV) history immune response immune responses immunization implicated induce Infectious diseases Inflammation management mechanism mediation molecules Pathogenesis Perspective recent released shown state target Therapeutic strategies Therapeutics Treatment Usage vaccination Vaccine Vaccines Vesicle [DOI] 10.3389/fimmu.2021.711565 PMC 바로가기 [Article Type] Review
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversionCOVID-19의 고해상도 혈청 프로테옴 궤적은 환자별 혈청 전환을 나타냅니다Article Published on 2021-07-072022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Analysis antibody apoA1 APOC1 APOC2 APOC3 APOH applied association biobanking Biological functions biological processes Biomarker Biomarkers CD14 changed clinical chemistry clinical chemistry parameters Coagulation Coagulation system commonality Control controls correlation Course COVID‐19 COVID‐19 patient COVID‐19 patients CRP FIVE FN1 foundation functional group Hospitalized HRG immunoassay Immunoglobulin immunoglobulins individual‐specific innate immune innate immune system KNG1 LBP LGALS3BP lipid homeostasis longitudinal samples mass spectrometry Microbiology, Virology & Host Pathogen Interaction molecular pathophysiological pathophysiology patients PLG PON1 Protein Proteins proteome proteomics provide quantified Region regions Regulation regulator Saa1 SARS‐CoV‐2 SARS‐CoV‐2 Seroconversion serum serum sample significantly symptomatic the disease therapeutic targets trajectory were measured [DOI] 10.15252/emmm.202114167 PMC 바로가기 [Article Type] Article