Novel pulmonary vascular imaging signs in COVID-19: pathophysiology, significance and managementOpinion Published on 2021-07-052022-10-28 Journal: BJR Open [Category] COVID-19, [키워드] biochemical COVID-19 demonstrated endothelial Evidence exploration Health immune management novel pathophysiology pericyte potential therapy thrombotic Treatment Vascular [DOI] 10.1259/bjro.20210001 PMC 바로가기 [Article Type] Opinion
The soluble catalytic ectodomain of ACE2 a biomarker of cardiac remodelling: new insights for heart failure and COVID19심장 리모델링의 바이오마커인 ACE2의 가용성 촉매 엑토도메인: 심부전 및 COVID19에 대한 새로운 통찰력Review Published on 2021-07-012022-09-11 Journal: Heart failure reviews [Category] MERS, SARS, 바이오마커, [키워드] ACE2 angiotensin Angiotensin 1-7 Angiotensin-converting enzyme angiotensin-converting enzyme 2 biochemical Biomarker body fluids cardiac remodelling cardiovascular disease catalytic chelation Chelation therapy COVID-19 COVID-19 infection COVID19 ectodomain Evidence function heart failure Increasing Local lung Lung injury membrane molecular plasma potential therapy Protective provided regulate Renin renin-angiotensin system SARS-CoV-2 soluble ACE2 soluble catalytic ectodomain of ACE2. tissues transmembrane protein type I [DOI] 10.1007/s10741-020-10066-6 PMC 바로가기 [Article Type] Review
Antimicrobial Peptides and Physical Activity: A Great Hope against COVID 19Review Published on 2021-06-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] accompanied adaptive immune responses addition adjuvants Alter AMP AMPs antimicrobial antimicrobial peptide antiviral properties antiviral property Cathelicidin chemokine Chemokine receptor chemokine receptors Complete coronavirus disease COVID 19 COVID-19 COVID-19 pathogenesis defensin derivative disrupting effective example healthy Hope Host immune increase in information Interaction Isolation mechanism microorganisms modulate physical activity potential therapy public health receptor receptors serum shown Support therapy TLRs Toll-like receptor Treatment Vaccine virus [DOI] 10.3390/microorganisms9071415 PMC 바로가기 [Article Type] Review
Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infectionSARS-CoV-2 감염에서 항염증제로서의 FluoxetineArticle Published on 2021-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 유전자 메커니즘, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus Admission Anti-inflammatory effects Anti-inflammatory therapy antidepressants Asthma B cell caused cell line cell lines Clinical outcome complex coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine IL6 Cytokine storm disease downstream drug Fluoxetine gp130 Hyperinflammatory response hyperinflammatory state identify IL6 IL6R IL6ST increase Infection Inflammation inflammatory pathways intensive care intensive care unit admission interact interleukin 6 knockdown mechanism Mortality NF-κB NFkB1 nuclear Nuclear factor kappa B subunit 1 Organ failure Patient potential therapy Protein receptor regulate respiratory SARS-CoV-2 SARS-COV-2 infection Selective serotonin reuptake inhibitors Sepsis Serotonin severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signal transduction SSRIs subunit suppressed target gene transcription factor Transcription factor NF-κB. transcriptomic variety [DOI] 10.1016/j.biopha.2021.111437 PMC 바로가기 [Article Type] Article
Developments in Treatment Methodologies Using Dendrimers for Infectious DiseasesReview Published on 2021-05-312022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] antibody Antimicrobial therapy Antiviral agents antiviral therapy Bacteria biochemical Compound contrast agent dendrimer dendrimers development diagnostic diagnostics Diseases drug delivery genetic material Infectious disease Infectious diseases macromolecules medium methodology MRI Nanoparticles parasites peptide polymers potential therapy structural property substrate therapeutic Transport Vaccine viruses [DOI] 10.3390/molecules26113304 PMC 바로가기 [Article Type] Review
Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19Immunology Published on 2021-05-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] activity approach attack Bacteria cellular immunity COVID-19 database Defense Demonstrating Diseases displaying effective elicit Glycosides highlight humoral immune system immunomodulation immunomodulator Including Infection Isolated management mechanism mechanisms microorganism modulate molecule MOST natural nonspecific Phytoconstituents plant plants Potential potential therapy reported Research researcher responsible Safe searched therapeutic potential Traditional Chinese medicine Viral diseases viral infections virus [DOI] 10.3389/fimmu.2021.637553 PMC 바로가기 [Article Type] Immunology
Recent knowledge in favor of remdesivir (GS-5734) as a therapeutic option for the COVID-19 infectionsCOVID-19 감염에 대한 치료 옵션으로 렘데시비르(GS-5734)에 찬성하는 최근 지식Review Published on 2021-05-012022-09-11 Journal: Journal of infection and public health [Category] Coronavirus, SARS, 신약개발, 치료제, [키워드] clinical clinical effectiveness Clinical tests clinical trial Coronaviruses COVID-19 COVID-19 infection evaluated favor GS-5734 in vitro in vivo knowledge management mechanism mechanism of action MERS MERS-CoV Outbreaks potential therapies potential therapy recent Remdesivir SARS-CoV SARS-CoV-2 Therapeutic approach therapeutic option virus replication [DOI] 10.1016/j.jiph.2021.02.006 PMC 바로가기 [Article Type] Review
Multicentre randomised double-blinded placebo-controlled trial of favipiravir in adults with mild COVID-19경증 COVID-19 성인을 대상으로 한 favipiravir의 다기관 무작위 이중 맹검 위약 대조 시험Article Published on 2021-04-142022-09-11 Journal: BMJ Open [Category] 임상, [키워드] 1:1 Affair approved blinded by mouth caused clinical clinical trials control group Coronavirus infection COVID-19 COVID-19 sample Cox proportional hazard regression decrease diagnosed disease onset double-blind double-blinded dropout rate Efficacy and safety Eligible participants Ethics evaluate the effect evaluated Evidence Favipiravir follow-up period followed by hazard ratio healthcare hypothesise Infectious diseases institutional review board intention to treat International King lack limit medication men Mild Ministry of Health mouth nonpregnant Novel coronavirus outbreak outcome participant Patient PCR PCR test peer-reviewed per day physician Placebo placebo-controlled trial positive potential therapy primary analysis population Primary outcome randomised Randomised trial recruit recruited registration number registry reported required Respiratory illness SARS-CoV-2 subject swab sample symptomatic patient Symptomatic patients the timing therapeutic agent Therapeutics therapy treat treated Treatment Virology virus virus clearance women [DOI] 10.1136/bmjopen-2020-047495 PMC 바로가기 [Article Type] Article
Involvement of Interleukin-1 Receptor-Associated Kinase 4 and Interferon Regulatory Factor 5 in the Immunopathogenesis of SARS-CoV-2 Infection: Implications for the Treatment of COVID-19Immunology Published on 2021-04-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] “cytokine storm” activated Adaptive immunity chemokine COVID-19 cytokine Cytokine storm Factor hyperinflammatory state IL-1 inhibitor innate immune response Innate immunity interferon regulatory factor interleukin-1 Involvement irak4 IRF5 kinase Ligand M1 macrophages membranes microbial infection morbidity and mortality NF-κB Pellino-1 plasma potential therapy Proinflammatory cytokine receptor required SARS-CoV-2 signaling pathway synergistic TLR transcription factors [DOI] 10.3389/fimmu.2021.638446 PMC 바로가기 [Article Type] Immunology
No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity질병 중증도가 다른 COVID-19 환자의 회복기 혈장에서 SARS-CoV-2 RNA가 검출되지 않음Article Published on 2021-04-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 asymptomatic patients Blood Chain Reaction collected Comorbidities contribute convalescent convalescent plasma coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients date of onset defined demographics disappearance disease severity Donor donor blood donors initial symptom initial symptoms investigated Japan male mechanical ventilation median age median time Mild moderate oxygen oxygen demand Passive passive immunization Patient patients plasma sample plasma samples Plasma transfusion Pneumonia polymerase chain polymerase chain reaction positive potential therapy proof Quality control real-time polymerase chain reaction recovered COVID-19 patient Recovered COVID-19 patients report resolved RNA SARS-CoV-2 SARS-CoV-2 RNA screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease severe symptoms severity treating COVID-19 patient Treatment [DOI] 10.1016/j.jiac.2021.01.004 PMC 바로가기 [Article Type] Article