Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19COVID-19와 관련된 숙주 유전자의 우선 순위를 지정하기 위한 동적 데이터 기반 메타 분석Meta-Analysis Published on 2020-12-182022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, 치료제, [키워드] Algorithm Betacoronavirus CD3E CD4 chromosome chromosome 3 conducted content COVID-19 COVID-19 pathogenesis CXCL10 cyclosporine data-driven datasets described disease-associated dynamic evaluate Evidence experiment Factor Factors FYCO1 GWAS Host host gene host genes human betacoronavirus IL1A Immunogenetics immunology implicated Infection Infectious diseases Interpretation list list of gene locus MERS MERS-CoV Meta-analysis Other PPIA Prognostic factor Prognostic factors resource robust SARS-CoV SARS-CoV-2 seasonal coronaviruses systematic review therapeutic target Therapies viral infection Weighting [DOI] 10.1038/s41598-020-79033-3 PMC 바로가기 [Article Type] Meta-Analysis
Genetic mechanisms of critical illness in COVID-19 Research Published on 2020-12-012022-10-05 Journal: Nature [Category] 신약개발, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] Antiviral association caused CCR2 chemotactic chromosome Clinical practice coronavirus disease COVID-19 Critical Critically ill patient dipeptidyl peptidase drugs ENCODE enzyme activator Evidence expression gene cluster Genetic Genetic variant Genome-wide association study genome-wide significant GenOMICC Host identify IFNAR2 Inflammatory intensive care units life-threatening low expression Lung inflammation lung tissue mechanism mendelian randomization OAS1 OAS2 organ damage randomized clinical trial receptor replicated robust severe COVID-19 target the interferon therapeutic transcriptome-wide Treatment TYK2 tyrosine with COVID-19 [DOI] 10.1038/s41586-020-03065-y [Article Type] Research
Short telomeres increase the risk of severe COVID-19Research Paper Published on 2020-10-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, [키워드] Admission age Autopsy baseline biological parameters C-reactive protein cellular chromosome chronic disease Cohort coronavirus disease correlated COVID-19 COVID-19 patient Critical disease death defined detect distribution DNA sequence healthy volunteers heterogeneous higher risk hospitalized COVID-19 patient ICU immune cells individual influence intensive care lung tissue marker Mortality Neutrophil-to-lymphocyte ratio non-survivor Older age outcome outcomes Patient proportion Prospective Study PROTECT risk risk factor severe COVID-19 severity significantly higher telomere Telomere Length the disease [DOI] 10.18632/aging.104097 PMC 바로가기 [Article Type] Research Paper
A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism긴 서열 판독을 기반으로 한 새로운 국내 고양이 게놈 어셈블리는 고양이 게놈 의학에 힘을 실어주고 왜소증에 대한 새로운 유전자를 식별합니다Research Article Published on 2020-10-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aligned allele analyses Analysis Author Biology Biosynthesis Cancer candidate cats chromosome complex correlated Deleterious disease distribution duplication dwarfism expansion facilitate FBXW7 Felis framework Genome genome assembly genomic genomic variation Glucose Health help Households human gene Human genetics humans identify Impact IMPROVE information involved landscape lead Lineage lymphoma Mutation mutations nucleotide patients phenotype Phenotypes predicted rare diseases reference genome resource screened sequence sequence variation significantly Single nucleotide variant single nucleotide variants SNV SNVs Structural variant structural variants susceptibility SVs Tumor tumor suppressor UGDH USA utility variant Variation whole genome sequence [DOI] 10.1371/journal.pgen.1008926 PMC 바로가기 [Article Type] Research Article
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals Research Published on 2020-09-302022-10-05 Journal: Nature [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome Asia association carried chromosome Cluster coronavirus coronavirus disease COVID-19 Europe gene cluster Genetic genetic risk factor genomic Hospitalization hospitalized patient individual Infection locus Neanderthal Respiratory failure risk SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe symptom [DOI] 10.1038/s41586-020-2818-3 [Article Type] Research
Rescue of SARS-CoV-2 from a Single Bacterial Artificial ChromosomeResearch Article Published on 2020-09-252022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] activity acute respiratory syndrome animal model Antiviral approach approved artificial BAC Bacterial biology of SARS-CoV-2 caused cDNA China chromosome clone comparable contribute coronavirus CoV COVID-19 COVID-19 disease cultured cell develop disease drug effort exhibited facilitate Factor feasibility feature food genetics growth hamsters Health impacted in viral in vitro in vivo involved knowledge lung nasal turbinate pandemic pandemic coronavirus Pathogenesis phenotype public health question recombinant recombinant virus Replication rescue rescued reverse genetics SARS-CoV-2 SARS-COV-2 infection shown Spread the SARS-CoV-2 Treatment triggered USA-WA1/2020 Vaccine Vaccine development VERO E6 cells Wuhan [DOI] 10.1128/mBio.02168-20 PMC 바로가기 [Article Type] Research Article
Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesisReview article Published on 2020-09-012022-10-05 Journal: Journal of infection and public health [Category] SARS, 유전자 메커니즘, [키워드] addition adenine Affect Ageing alteration antigen-presenting cell biological function Cellular immune response change chromosome circulating pro-inflammatory cytokine Complication COVID 19 COVID-19 COVID-19 patient Cytokine storm death dinucleotide Effects elderly Factor Gas exchange Hospitalization Hypothesis immune Immune cell immune function immune system immunomodulator impairment increase in Increasing influence inhibitory effect lung lymphocyte morbidity and mortality NAD+ positive Prevent pro-inflammatory cytokine Respiratory function risk sensitivity Severe infection stability susceptibility telomere telomeres [DOI] 10.1016/j.jiph.2020.06.004 [Article Type] Review article
Endogenization and excision of human herpesvirus 6 in human genomes인간 게놈에서 인간 헤르페스바이러스 6의 내생성 및 절제Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affecting association childhood chromosome chromosome 22q chromosomes contribute described direct repeats Diseases DRs East Asians Evolution excision expected explain Genome genome sequence Genome sequences germline germlines HHV-6 HHV-6A HHV-6B homologous Human Human genome Human genomes human herpesvirus 6 humans in vivo infect Infectious virus integration Japan Japanese Japanese people leads life locus MOST MOV10L1 nuclear physically PIWI-interacting RNAs polymorphism Polymorphisms question raise Reactivation Recombination reported required risk RNA screened sequence sequences solo-DR subject subtelomere telomere telomeres transposons variant Viral viral genome viral reactivation virus WGS whole-genome sequencing [DOI] 10.1371/journal.pgen.1008915 PMC 바로가기 [Article Type] Research Article
Molecular mechanisms of sex bias differences in COVID-19 mortalityViewpoint Published on 2020-07-092022-11-01 Journal: Critical Care [Category] COVID-19, [키워드] androgen angiotensin-converting enzyme 2 antagonist approach cellular chromosome chromosomes Compound contribute COVID-19 COVID-19 mortality died Estrogen explain fatality hormone immune response Innate immunity lack mechanism men nucleic acids patients with COVID-19 receptor SARS-CoV-2 Sex sex hormone T cell activation Toll-like receptor women X chromosome [DOI] 10.1186/s13054-020-03118-8 PMC 바로가기 [Article Type] Viewpoint
Analysis of HBV Genomes Integrated into the Genomes of Human Hepatoma PLC/PRF/5 Cells by HBV Sequence Capture-Based Next-Generation SequencingArticle Published on 2020-06-182023-06-03 Journal: Genes [Category] B형 간염, [키워드] chromosome HBV HCC Hepatocarcinogenesis Huh7 integration Next-generation sequencing PLC/PRF/5 transfection [DOI] 10.3390/genes11060661 PMC 바로가기 [Article Type] Article