Trends and targets of various types of stem cell derived transfusable RBC substitution therapy: Obstacles that need to be converted to opportunity다양한 형태의 줄기세포 유래 수혈적혈구 대체요법의 동향 및 목표: 기회로 전환되어야 할 장애물Review Published on 2020-10-012022-09-11 Journal: Transfusion and apheresis science : official journ [Category] 비임상, [키워드] approach artificial artificial intelligence Bioreactors Blood Blood Group blood supply breath Cell cellular clinical trial Combination complex Compliance COVID-19 Critical Culture dependency Donor Efficiency embryonic employment example expansion Expansion media GMP GMP regulatory processes hematological Hematopoietic stem cell hematopoietic stem cells highlight in vitro In-vitro induced Induced pluripotent stem cell life maintenance media metabolic pathway metabolic pathways metabolite metabolites New obstacle outbreak overcome pandemic produced RBC RBCs regenerative regenerative medicine Regulatory required Safe stability STEM stem cell stem cells target Transfusable RBC bioproducts. transfusion trend Variability [DOI] 10.1016/j.transci.2020.102941 PMC 바로가기 [Article Type] Review
Research progress on Mesenchymal Stem Cells (MSCs), Adipose-Derived Mesenchymal Stem Cells (AD-MSCs), Drugs, and Vaccines in Inhibiting COVID-19 DiseaseReview Article Published on 2020-10-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] acute respiratory distress Adipose Stem Cells administration affected Anti-inflammatory Anti-viral Anti-viral therapy antiviral therapy caused cellular clinically coagulation dysfunction Complication coronavirus 2 coronavirus disease Coronavirus therapy COVID-19 COVID-19 disease COVID-19 patient death drug effective drug ENhance expected homing IMPROVE intravenous lack literature review Mesenchymal stem cells microenvironment microRNA MSC MSCs multiple organ failure Patient patients promote reduce regenerative reported Research respiratory activity risk SARS-CoV-2 Sepsis STEM Stem cell therapy surgical syndrome therapy tissue repair Vaccine virus [DOI] 10.14336/AD.2020.0711 PMC 바로가기 [Article Type] Review Article
The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019Review Published on 2020-09-212022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] absence acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome alleviate Antiviral ARDS arise changed clinical trial common condition coronavirus coronavirus disease Coronavirus infections Coronavirus-2 COVID-19 critically ill patients curtail death disease drug Effect Host host-response immune response immunomodulatory properties Infection intensive care Mesenchymal stromal cells Middle East MSC MSCs multiple sclerosis Osteoarthritis outbreak pandemic Patient potential treatments reduce regenerative Safe SARS-CoV-2 SARS-COV-2 infection Seven severity Spread stromal cell syndrome therapy Treatment Vaccine while [DOI] 10.1186/s12967-020-02532-4 PMC 바로가기 [Article Type] Review
Regen med therapeutic opportunities for fighting COVID ‐19Perspectives Published on 2020-08-272022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, [키워드] animal model animal models COVID COVID‐19 COVID‐19 drug evaluate help highlight identify lung mechanism of action Medicine mesenchymal stromal/stem cells organ systems organoids pandemic patients Perspective physiological platform regenerative regenerative medicine resource SARS‐CoV‐2 SARS‐CoV‐2 Scientific community Society therapeutic therapy virus [DOI] 10.1002/sctm.20-0245 PMC 바로가기 [Article Type] Perspectives
Immune Dysfunction and Multiple Treatment Modalities for the SARS-CoV-2 Pandemic: Races of Uncontrolled Running Sweat?Review Published on 2020-08-242022-10-28 Journal: Biology [Category] COVID-19, [키워드] acute respiratory syndrome adoptive cell-based therapy anti-neoplastic regimen Antigen caused cells chimeric clinical trial clinical trials Community confirmed case coronavirus coronavirus disease COVID-19 Cytokine storm death deregulation Extracellular Extracellular vesicles global pandemic high mortality Host immune Immune cell immunomodulatory immunomodulatory drugs Infection lack Mesenchymal stem cells modality Multiple natural killer outcome pharmaceutical intervention Protective race receptors reduce regenerative regimen regimens risk running SARS-CoV-2 SARS-CoV-2 pathogenesis selected shown Spread Stem cell therapy the SARS-CoV-2 therapeutic therapeutic strategy therapy Treatment treatment strategy uncontrolled Vaccine [DOI] 10.3390/biology9090243 PMC 바로가기 [Article Type] Review
Coronavirus disease 2019: A tissue engineering and regenerative medicine perspectiveConcise Review Published on 2020-08-212022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, [키워드] acute respiratory distress acute respiratory distress syndrome antiviral agent Antiviral agents ARDS biomaterial caused cell processing clinical trial clinical trials conducted Coronavirus infections COVID‐19 current death derivative described disease Disease progression driving Effect effective Efficacy evaluate Exosomes Impact infective Inflammation Last majority medical need mesenchymal stem cell MSC MSC therapy MSCs novel coronavirus disease pandemic Perspective platform progression regenerative required Research Safe stem cell syndrome the disease Therapeutic benefit Therapies therapy tissue Treatment Vaccine [DOI] 10.1002/sctm.20-0197 PMC 바로가기 [Article Type] Concise Review
The Coronavirus Pandemic (SARS-CoV-2): New Problems Demand New Solutions, the Alternative of Mesenchymal (Stem) Stromal CellsCell and Developmental Biology Published on 2020-07-162022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Anti-inflammatory approach caused clinical study COVID-19 Demand Exosomes Extracellular vesicles heterogeneity Mesenchymal stromal cell MSC New patients with COVID-19 problem regenerative Research SARS-CoV-2 STEM stromal cell the cytokine storm therapeutic treat [DOI] 10.3389/fcell.2020.00645 PMC 바로가기 [Article Type] Cell and Developmental Biology
Mesenchymal stem cell derived extracellular vesicles: promising immunomodulators against autoimmune, autoinflammatory disorders and SARS-CoV-2 infectionArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] Activation adaptive affecting Autoimmune Autoimmunity being binding Cell cell membrane Characteristics clinical setting clinical study component COVID-19 Critical Cytokine storm Cytokines cytosolic disorder effective EVs exceptional Exosome Exosomes Extensive Extracellular extracellular vesicle Extracellular vesicles Factor function Growth factors immune immune cells Immunological disorders immunomodulator Inflammation inflammatory disease Inflammatory response inhibiting Intercellular communication investigated lower risk Lung pathology membrane mesenchymal stem cell Mesenchymal stem cells Microvesicles Migration miRNA Mortality mRNA MSC MSCs outcome pandemic paracrine parent cells pathway proliferation regenerative regulate rejection Research SARS-CoV-2 SARS-COV-2 infection secreted secretion target cell tested therapeutic agent Therapies therapy tolerogenic immune response transcription factors Treatment triggered unique variety [DOI] 10.3906/biy-2002-79 PMC 바로가기 [Article Type] Article
Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID ‐19Concise Review Published on 2020-06-112022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, [키워드] accompanied accumulated acute respiratory distress Allogeneic ARDS Asthma Bacterial bacterial pneumonia chronic obstructive clinical trial Clinical use COPD COVID COVID‐19 COVID‐19 curative current Cytokine storm disease Diseases disorder disorders Effect effective Evidence Gleaning Idiopathic pulmonary fibrosis immunomodulatory property Influenza lack lung lung disorders mesenchymal stem cell Mesenchymal stem cells mortality rate MSC MSC therapy MSCs novel coronavirus disease outcomes pandemic Perspective preclinical data pulmonary conditions pulmonary disease pulmonary injury regenerative reported stem cell Stem cell therapy syndrome therapeutic therapeutic use therapy [DOI] 10.1002/sctm.20-0186 PMC 바로가기 [Article Type] Concise Review
Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19Opinion Article Published on 2020-05-112022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome Adaptive immune response Alzheimer’s disease Alzheimer’s disease approach Bacterial Brain Chemotherapy cognitive coronavirus disease COVID-19 develop disorder Down syndrome drug Effect effective Encephalitis GM-CSF granulocyte-macrophage colony-stimulating factor humans Immunity imperative Inflammation innate immune system Intervention investigated mouse model Neuroinflammation Nile Other other diseases pandemic pathology Patient recruitment regenerative respiratory SARS-CoV-2 shown stimulate treated Treatment Viral diseases viral infections viral pneumonias virus West West Nile Virus [DOI] 10.12688/f1000research.23729.1 PMC 바로가기 [Article Type] Opinion Article