Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, ItalyObservational Study Published on 2021-07-012022-10-05 Journal: Journal of Neurology [Category] 임상, [키워드] 95% CI accumulating Altered Altered mental status Analysis anti-SARS-CoV-2 attacks Bergamo categories cerebrovascular Cerebrovascular disease cerebrovascular diseases clinician COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom CSF disorders Encephalitis had more Infectious diseases information Italy large cohort manifestation manifested Mental nervous nervous system nervous system disease neurologic neurological Neurological complication offer Patient peripheral peripheral neuropathies presenting RNA RT-PCR detection SARS-CoV-2 SARS-COV-2 infection severe ARDS Symptom Therapeutic strategies venous [DOI] 10.1007/s00415-020-10251-5 PMC 바로가기 [Article Type] Observational Study
COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operativelyCOVID-19(SARS-CoV-2) 림프구 반응은 수술 전 총 관절 교체 수술 후보의 염증성 바이오마커와 관련이 있습니다Research Article Published on 2021-06-302022-09-10 Journal: Journal of Orthopaedic Surgery and Research [Category] MERS, SARS, 바이오마커, 치료법, [키워드] addition analyzed antibodies antibody antibody production Blood candidate Cohort coronavirus COVID-19 cross-reactivity elective surgeries Elective surgery exhibited exposure to General population IgG antibodies IgG antibody IL-1ra IL-1β IL-6 Immunity Inflammatory biomarker inflammatory biomarkers joint LTT lymphocyte lymphocyte response lymphocyte responses Lymphocytes median age memory nucleocapsid nucleocapsid protein Nucleocapsid proteins parameter Patient peripheral Peripheral blood positive pre-vaccination pro-inflammatory biomarkers profiles protective immunity Protein reactive reactivity recent Registered response Result Retrospective study risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid SARS-CoV-2 virus serum spike and nucleocapsid proteins Spike protein Spike proteins T cell T cell memory the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein TNFα Total Total joint arthroplasty Trial registration vaccination vaccination Methods [DOI] 10.1186/s13018-021-02563-7 PMC 바로가기 [Article Type] Research Article
Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World ManagementObservational Study Published on 2021-06-292022-10-04 Journal: Medicina [Category] MERS, SARS, 임상, [키워드] Abdominal aortic aneurysm analyzed aortic aneurysm Artery benefit cardiovascular risk COVID-19 COVID-19 pandemic disease drug Follow-up High-risk patients higher risk impacted LDL limitations Lipid lipid profile low-density management material Modification Mortality objective offer Patient patients peripheral Peripheral artery disease profile reducing required Result risk risk reduction Surveillance survival targets the mean therapeutic target therapy treated unit were recorded [DOI] 10.3390/medicina57070672 PMC 바로가기 [Article Type] Observational Study
Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine SeroconversionArticle Published on 2021-06-252022-10-31 Journal: Genes [Category] COVID-19, [키워드] 95% CI applied approach AUC B cell B lymphocyte B lymphocytes Biomarker blood transcriptome Cell clinical setting collected correlated COVID-19 COVID-19 vaccines datasets determine develop Direct expressed expression FCRLA Gene Expression gene expression dataset Genes greater immunology Influenza leukocyte log measurement mononuclear cells pathway PBMC peripheral Peripheral blood Precision predict predicted prediction Predictive proportion purified reference gene Responder sensitivity Seroconversion SMD subpopulation subpopulations target gene TNFRSF13C TNFRSF17 transcript transcript abundance Transcriptome Trial TXNDC5 vaccination was used [DOI] 10.3390/genes12070971 PMC 바로가기 [Article Type] Article
Multilevel diabetic foot revascularization in COVID 19 patient: Case reportCase Report Published on 2021-06-242022-10-30 Journal: International Journal of Surgery Case Reports [Category] COVID-19, [키워드] accelerate association benefit blood flow Case report complementary complex COVID 19 COVID-19 COVID-19 infection COVID-19 patient Critical death Diabetic diabetic foot diabetic patient disease distal Efficacy Endothelial dysfunction endothelial injury Evolution feasible higher risk hybrid Hybrid procedure hypercoagulable Infection intensive care Intervention Ischemia lesion limb morbidity outcome Patient performed peripheral Peripheral arterial disease presentation presenting progression reduce reduced reported required risk risk factor Safe severity Simultaneous treatment surgical thrombosis Treatment vascular disease virus viruses [DOI] 10.1016/j.ijscr.2021.106132 PMC 바로가기 [Article Type] Case Report
Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients강력한 SARS-CoV-2-특이적 T 세포 면역 및 낮은 아나필라톡신 수치는 COVID-19 환자의 경증 질병 진행과 상관관계가 있습니다Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] addition analyzed anaphylatoxin anaphylatoxin C3a Antibody titer Antibody titers Blood C5a caused CD4 CD8 cellular characterized clearance Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient disease severity elevated ELISA ELISPOT ELISpot assay evaluated flow cytometry healthy individual highest humoral immune response IFNγ IgG immune complex immune responses immunodominant indicate infected individuals Level Lymphocytes lymphopenia Mild mild infections mononuclear cell mononuclear cells Mortality neutralization ability neutralizing Abs Neutralizing activity nucleocapsid Patient patients peptide peptide pool peripheral Peripheral blood Peripheral blood mononuclear cells potent reduced respiratory Respiratory system robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-infected individuals SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe disease progression significantly specific antibodies Spike proteins T cell T cell immunity T cell response T cell responses T cells T lymphocyte Viral viral infection viral infections [DOI] 10.3389/fimmu.2021.684014 PMC 바로가기 [Article Type] Immunology
Peripheral and lung resident memory T cell responses against SARS-CoV-2SARS-CoV-2에 대한 말초 및 폐 상주 기억 T 세포 반응Article Published on 2021-05-212022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] acute infection Anti-inflammatory Antiviral antiviral response Apoptosis apoptotic Biopsy material Blood CCR7 Cell cellular immunity circulating Clinical outcome Convalescent patients COVID-19 Cytokines degranulation disease severity functional highlight identify IFNγ IL-10 IL-12p70 IL-4 IL-4 responses Infection Infectious diseases initial limit lung lung biopsy lung parenchyma Lungs memory T memory T cell memory T cells modulated Mucosal immunology outcome Patient patients with COVID-19 peptide peptides peripheral persistence positioned profiles reduce Reinfection required resident respiratory respiratory tract response responses against SARS-CoV-2 SARS-COV-2 infection secreting severity Spread T cell T cell response T cell responses T cells these cell These cells Viral viral infection Viral protein Viral proteins virus-specific T cell window [DOI] 10.1038/s41467-021-23333-3 PMC 바로가기 [Article Type] Article
Circulating Type I Interferon Levels and COVID-19 Severity: A Systematic Review and Meta-Analysis순환하는 제1형 인터페론 수치와 COVID-19 심각도: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-05-122022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age antiviral response antiviral responses article association Biomarker can not caused clinical evolution clinical manifestation clinical manifestations clinical status Comparative complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical critical COVID-19 patients critical patients cytokine Cytokines database demonstrated determine disease severity elevated evaluated Evidence evidence of healthy individual healthy individuals IFN-α IFN-I IFN-α immunological alteration infections interferon interferon response interferons Level limit of detection marker means Meta-analysis Mild mild cases Mild disease no significant difference outcome outcomes Pathogenesis Patient patients performed peripheral plasma Plasma levels plasma protein random effect Reporting respiratory Result resulting review SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases Severe patient severity severity of COVID-19 Sex significant difference SMD standardized mean difference the MEDLINE Type Type I IFN type I interferon type I interferons was measured was performed Web of Science with mild disease [DOI] 10.3389/fimmu.2021.657363 PMC 바로가기 [Article Type] Meta-Analysis
Peripheral blood microRNAs and the COVID-19 patient: methodological considerations, technical challenges and practice points말초혈액 microRNA와 COVID-19 환자: 방법론적 고려사항, 기술적 과제 및 실천 포인트Review Published on 2021-05-012022-09-11 Journal: RNA Biology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addressed among others Analysis angiotensin Angiotensin-converting enzyme ARDS Biomarker biopsies Blood circulating circulating miRNA profile circulating miRNA profiles Clinical practice coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 emergency COVID-19 patients detection Early detection experimental design heparin infection with SARS-CoV-2 Interpretation liquid biopsy LMWH low molecular weight low molecular weight heparin management methodological Methods microRNA MicroRNAs miRNA miRNA signature miRNAs ncRNA noncoding RNA pandemic peripheral public health qPCR reproducibility respiratory respiratory distress resulting rigour robust RT-qPCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus transcriptomic translation variable [DOI] 10.1080/15476286.2021.1885188 PMC 바로가기 [Article Type] Review
Bone Marrow and Peripheral Blood Findings in Patients Infected by SARS-CoV-2SARS-CoV-2에 감염된 환자의 골수 및 말초 혈액 소견Article Published on 2021-04-262022-08-31 Journal: American journal of clinical pathology [Category] MERS, 바이오마커, [키워드] 8 women Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anemia Autopsy Blood bone Bone marrow calculated caused CBC clinical Coinfection coronavirus coronavirus disease coronavirus disease 19 COVID-19 Deceased Evidence evidence of examined finding hematologic Hematopoiesis Hemophagocytosis HLH immunohistochemical stains Laboratory Leukocytosis lymphopenia Marrow median men neutrophilic leukocytosis one patient Patient patients patients with COVID-19 peripheral Peripheral blood polycythemia ranged respiratory risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus thrombocytopenia women [DOI] 10.1093/ajcp/aqaa274 PMC 바로가기 [Article Type] Article