A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
COVID-19에 대한 질병 징후 및 약물 용도 변경에 대한 조사 및 인구 기반 검증에 대한 네트워크 의학 접근 방식
Observational Study
[키워드] 95% CI
ACE2
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
ADRB2
African American
African Americans
age
Analysis
angiotensin
Angiotensin II
angiotensin-converting enzyme inhibitor
angiotensin-converting enzyme inhibitors
approach
approved
Asthma
asthma patient
asthma patients
blocker
candidate
caused
Chain Reaction
co-expression
Comorbidity
Consequences
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
Crohn disease
database
disease
disease manifestation
elevated
Enterocyte
host protein
identify
ileal
increase
individual
Inflammatory
Inflammatory bowel disease
IRAK3
Laboratory
Laboratory test
likelihood
Manifestations
mechanism
Medical conditions
melatonin
metabolomics
methodology
molecular
morbidity
morbidity and mortality
network
observation
observational study
Odds ratio
pandemic
Pathogenesis
Patient
platform
positive
positive test result
potential treatments
Propensity score
protein interactions
protein–protein interactions
proteome
proteomics
receptor
Receptor Blockers
reduced
respiratory
risk
SARS-CoV-2
SARS-CoV-2 pathogenesis
SARS-CoV-2 virus
severe acute respiratory syndrome Coronavirus
Sex
significantly
single-cell
Single-cell RNA sequencing
smoking
test result
therapy
tissue
tissues
TMPRSS2
Transcriptome
transcriptomics
Treatment
treatment of COVID-19
widespread
with COVID-19
[DOI] 10.1371/journal.pbio.3000970 PMC 바로가기 [Article Type] Observational Study
[DOI] 10.1371/journal.pbio.3000970 PMC 바로가기 [Article Type] Observational Study