Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2Article Published on 2021-02-222022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] Amino acid amino acid residue Antigen binding cell membrane COVID-19 effective flexible hACE2 hACE2 receptor highest human Angiotensin-converting enzyme immune response infection process Infectious disease Interaction investigated MD simulations mechanism Molecular modelling Mutation NMA normal mode analysis novel coronavirus SARS-CoV-2 outbreak Protein RBD receptor receptor ACE2 Receptor binding domain residue S477N SARS-CoV-2 SARS-CoV-2 mutants Spike protein the disease the RBD the SARS-CoV-2 the spike protein variant viral infection virus [DOI] 10.1038/s41598-021-83761-5 PMC 바로가기 [Article Type] Article
Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infectionArticle Published on 2021-02-122022-10-04 Journal: Communications Biology [Category] MERS, 치료제, [키워드] accumulated ACE2 angiotensin approach binding binding site block Cell cell entry coronavirus disease COVID-19 exhibiting glycoprotein hACE2 hACE2 protein high affinity Human human cell IC50 Infection inhibit SARS-CoV-2 inhibitory concentration Invasion knowledge mimicking N-terminal peptide powerful tool Prophylactic receptor residue SARS-CoV-2 Structure-based drug design Therapeutic approach viral infection viral spike virus spike protein [DOI] 10.1038/s42003-021-01736-8 PMC 바로가기 [Article Type] Article
Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody인간 단일 클론 항체를 중화하여 SARS-CoV-2 치명적인 감염된 K18-hACE2 형질 전환 마우스의 노출 후 보호Article Published on 2021-02-112022-09-12 Journal: Nature Communications [Category] MERS, 변종, 진단, [키워드] Ablation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered administration antibody approach caused consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection days post infection days post-infection disease symptom disease symptoms Efficacy Efficiency evaluate exhibit hACE2 human monoclonal antibodies Human monoclonal antibody in vivo Infection Infectious diseases infective K18-hACE2 transgenic mice life load lung Lungs mice monoclonal morbidity Mortality Neutralizing Neutralizing antibodies neutralizing antibody pandemic pathogen preventing infection rescued respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection sociality supported therapeutic treated Treatment virion [DOI] 10.1038/s41467-021-21239-8 PMC 바로가기 [Article Type] Article
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamideTMPRSS2 발현에 대한 독특한 메커니즘은 엔잘루타미드에 의한 SARS-CoV-2 감염의 기관 특이적 억제를 설명합니다Article Published on 2021-02-082022-09-10 Journal: Nature Communications [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiandrogen antiviral action antiviral activity antiviral efficacy approved binding binding pattern Cancer cells caused Cell cells clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drugs Effect Efficacy enzalutamide epithelial cells evaluated Evidence explain expression Gene regulation global public health hACE2 human lung human lung cell human lung cells human lung organoid human lung organoids in vivo inhibited knockout mice lack locus lung cancer lung cell lung cells mechanism mediator mice organ-specific organoids pandemic Prostate Prostate cancer protective role reduce reducing Regulatory Repurposed drug respiratory SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus significantly Support therapeutic efficacy TMPRSS TMPRSS2 TMPRSS2 expression Tmprss2 knockout transmembrane serine protease transmembrane serine protease 2 treating COVID-19 [DOI] 10.1038/s41467-021-21171-x PMC 바로가기 [Article Type] Article
Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans스파이크 단백질과 인간 ACE2 간의 결합 능력 예측의 역학은 인간에서 SARS-CoV-2의 적응 전략을 보여줍니다Article Published on 2021-02-042022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Amino acid Analysis analyzed binding ability binding affinity collected Computational biology and bioinformatics conserved coronavirus country COVID-19 pandemic Dynamics Ethnic groups genome sequence hACE2 Host hosts Human human ACE2 Interaction Mutation natural reservoir Novel coronavirus Phylogenetic analysis Phylogeny plasticity RBD Receptor-binding domain recombination event reconstructed Region respiratory reveal S gene SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stability the receptor-binding domain the spike protein Transmission variant variants viral infection [DOI] 10.1038/s41598-021-82938-2 PMC 바로가기 [Article Type] Article
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2단일 용량 mRNA 백신은 SARS-CoV-2로부터 hACE2 형질전환 마우스를 장기간 보호합니다Article Published on 2021-02-032022-09-12 Journal: Nature Communications [Category] MERS, 진단, [키워드] Antibody Response BALB/c mice candidate Cellular responses clinical development clinical trial clinical trials convalescent patient Convalescent patients COVID-19 pandemic demonstrated elicited expressing global health hACE2 Health immunization induce late phase lung Lungs mice mRNA mRNA vaccine mRNA-based vaccine Neutralizing antibodies neutralizing antibody notable nucleoside nucleoside-modified mRNA provide provided raised rapid expansion RBD Re-infection regimen RNA vaccines robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 Spike RBD SARS-CoV-2 vaccine sera short duration single dose Taking the SARS-CoV-2 These data transfer transgenic mice vaccination Vaccine widespread [DOI] 10.1038/s41467-021-21037-2 PMC 바로가기 [Article Type] Article
A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2Spike RBD와 ACE2 간의 상호 작용 차단을 통한 항 SARS-CoV-2 약물의 새로운 스크리닝 전략Article Published on 2021-02-012022-08-31 Journal: Environment international [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin angiotensin converting enzyme anti-SARS-CoV-2 Anti-SARS-CoV-2 drugs screening strategy binding binding energy blockade Blockade mechanism Compound compounds Corona drug drug design Drug screening druggability eight enzyme exhibited hACE2 hesperidin highest human angiotensin converting enzyme 2 information Interaction investigated mechanism overcome pandemic RBD Receptor binding domain required S RBD SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD screening strategy spike Spread Structure Structure-activity relationship structures therapy Virus Disease [DOI] 10.1016/j.envint.2020.106361 PMC 바로가기 [Article Type] Article
A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection새로운 SARS-CoV-2 이중 목적 혈청 검사: 매우 정확한 감염 추적 및 중화 항체 반응 검출Virology Published on 2021-01-262022-09-10 Journal: Journal of Clinical Microbiology [Category] SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin antibodies antibody coronavirus detect detection domain Donor eight ELISA expected Extracellular hACE2 human Angiotensin-converting enzyme individual Interaction less neutralization test neutralization tests Neutralizing Neutralizing antibodies New patients positive purified RBD receptor Receptor binding domain Reinfection respiratory response SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain serology serology test serology tests Spike protein Support Surveillance sVNT tracing vaccinated individual vaccinated individuals Vaccines virus neutralization test [DOI] 10.1128/JCM.02438-20 PMC 바로가기 [Article Type] Virology
Multi-Organ Involvement in COVID-19: Beyond Pulmonary ManifestationsReview Published on 2021-01-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE-2 acute respiratory distress acute respiratory syndrome affecting angiotensin-converting enzyme-2 ARDS assumed Atypical being clinical presentation complications Coronavirus-2 COVID-19 death dermatological disease distribution droplet transmission fatality gastrointestinal symptoms hACE2 health emergency help hepatic illnesses Injury Involvement manifestation mechanism multi-organ dysfunction Multiorgan Myocardial dysfunction neurologic neurological organ-specific organotropism of SARS-CoV-2 Pathogenesis pathophysiology plethora Pneumonia progression proportion pulmonary receptors renal Research SARS-CoV-2 Spread syndrome the disease therapeutic strategy Therapeutics Transmission Vaccine Vaccines viral invasion [DOI] 10.3390/jcm10030446 PMC 바로가기 [Article Type] Review
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 MiceK18-hACE2 마우스에서 SARS-CoV-2의 비강내 접종 후 신경 침범 및 뇌염Article Published on 2021-01-192022-09-10 Journal: Viruses [Category] 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Brain brains Cell cell death Central nervous system characterized chemokines CNS Coronavirus-2 correlated COVID-19 cytokine Cytokines declined direct infection Encephalitis exhibited hACE2 hallmark hemorrhage highest humans infect cell Infection Infectious virus Inflammatory response inoculation intranasal K18-hACE2 K18-hACE2 mice leukocyte leukocyte infiltration lung Lungs mice Mortality nasal nasal turbinate Neuroinflammation neuroinvasion Neurological disease neuronal olfactory olfactory bulb Onset Pathogenesis pathogenesis of SARS-CoV-2 plaque-forming unit plaque-forming units respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe disease Viral virus titer virus titers [DOI] 10.3390/v13010132 PMC 바로가기 [Article Type] Article