Gastrointestinal Microenvironment and the Gut-Lung Axis in the Immune Responses of Severe COVID-19Molecular Biosciences Published on 2021-04-122022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome alleviate association axis caused coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 severity digestive tract Enteric infection Evidence Frequency Gastrointestinal global pandemic Gut gut-lung axis Health immune response immunopathology IMPROVE intestinal intestinal dysbiosis microenvironment morbidity and mortality outcome Prevent response SARS-CoV-2 severe COVID-19 severity of COVID-19 syndrome therapeutic potential [DOI] 10.3389/fmolb.2021.647508 PMC 바로가기 [Article Type] Molecular Biosciences
Post-traumatic stress symptoms among an Egyptian sample of post-remission COVID-19 survivors: prevalence and sociodemographic and clinical correlatesResearch Published on 2021-03-292022-10-29 Journal: Middle East Current Psychiatry [Category] COVID-19, [키워드] age axis clinical control subject control subjects convenience sampling COVID-19 COVID-19 survivors COVID-19 virus cross-sectional design DSM-5 Egypt evaluated HADS identify IES-R Impact individual Infection interview participant post-traumatic stress symptom Post-traumatic stress symptoms predicted Prevalence prevalent recruited reported Result scale severe COVID-19 symptom Sex Sociodemographic Spread stress symptom survived survivor Survivors Symptom symptom severity the disease university Zagazig [DOI] 10.1186/s43045-021-00102-y PMC 바로가기 [Article Type] Research
What Is the Impact of COVID-19 Pandemic on Patients with Pre-Existing Mood or Anxiety Disorder? An Observational Prospective StudyObservational Study Published on 2021-03-242022-10-04 Journal: Medicina [Category] SARS, 임상, [키워드] age Anxiety axis Bipolar disorder Care clinical condition consecutive patient consequence coronavirus COVID-19 criteria depressive diagnose disorder disorders DSM-5 explain Impact include investigated Italy lockdown major depressive disorder material mood not significant obsessive–compulsive disorder OCD offered Outpatient pandemic Panic disorder Patient Prospective Prospective Study Psychological psychological Impact Psychopathology recruited Rome social anxiety disorder Stress Symptoms their family member treated triggered worsened worsening [DOI] 10.3390/medicina57040304 PMC 바로가기 [Article Type] Observational Study
Gut-Lung Axis in COVID-19Review Article Published on 2021-03-122022-10-29 Journal: Interdisciplinary Perspectives on Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome axis caused coronavirus COVID-19 COVID-19 patient Gut Host Immunity Impact Infection Inflammation Interaction lung Microbiome pandemic pathogenicity Pulmonary function Respiratory system RNA SARS-CoV-2 Stool the gut-lung axis therapeutic approaches viral ribonucleic acid [DOI] 10.1155/2021/6655380 PMC 바로가기 [Article Type] Review Article
Microbiota Modulation of the Gut-Lung Axis in COVID-19COVID-19에서 장폐 축의 미생물총 조절Review Published on 2021-02-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, 치료기술, 치료제, [키워드] addition administration Affect affected Anti-inflammatory axis bidirectional caused condition consequence correlated COVID-19 COVID-19 patients deaths deregulation diarrhea digestive Diversity duodenum Dysbiosis exacerbated Fecal sample fecal samples gastrointestinal system gastrointestinal tract gastrointestinal tracts Gut gut microbiota gut-lung axis Health Organization immune immune response immune responses increased mortality Infectious disease Inflammation Interaction intestinal involved lung Lungs manifestation Manifestations mechanism microbiota modulation mucosa mucosal mucous membrane mucous membranes nasopharyngeal oesophagus other respiratory infections pathologic persistence Probiotics Prolonged rectum Regulatory respiratory respiratory and gastrointestinal tracts respiratory infections respiratory mucosa Respiratory system SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 stomach target the healthy Therapeutic approach therapy virus WHO World Health Organization [DOI] 10.3389/fimmu.2021.635471 PMC 바로가기 [Article Type] Review
SARS-CoV-2/human interactome reveals ACE2 locus crosstalk with the immune regulatory network in the hostSARS-CoV-2/인간 상호작용체는 숙주의 면역 조절 네트워크와 ACE2 유전자좌 누화를 밝힙니다Article Published on 2021-02-192022-09-11 Journal: Pathogens and disease [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 receptor ACE2/AGT-axis activating Activation acute respiratory syndrome adrenal gland Altered angiotensin angiotensin-converting enzyme 2 approach axis binding blood pressure body tissues carboxypeptidase Cell cell cycle changes in Complication coronavirus COVID-19 cytokine database determine develop event gene expression profile globe Health help Host host immune system host protein Human human Angiotensin-converting enzyme human lung human tissue immune immune modulation immune response in viral Infection infection site Interaction involved kidneys Lineage locus lung Lungs mechanism mechanisms modulate molecular network Occurrence organs pancreas Placenta Primary infection Protein Proteins proteomic RAS receptor regulated regulatory network Renin renin-angiotensin system Replication respiratory reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Severe acute respiratory syndrome Signal transduction small intestine Spike protein Testis tissues vascular remodelling Viral viral infection viral spike protein [DOI] 10.1093/femspd/ftab005 PMC 바로가기 [Article Type] Article
SARS CoV-2 Organotropism Associated Pathogenic Relationship of Gut-Brain Axis and IllnessMolecular Biosciences Published on 2020-12-222022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] abdomen ACE2 receptor Acute cardiac injury Acute kidney injury acute respiratory distress axis Characteristics chest pain China clinical manifestation coronavirus country CoV COVID-19 COVID-19 infection COVID-19 virus Cytokine storm death diarrhea disorder Dysbiosis emesis evaluate Exanthema extra-pulmonary organ fatigue Fever gastrointestinal tract Gut-brain axis hemoptysis illness infected with COVID-19 Infection Interaction involved laboratory-confirmed loss of appetite mechanism MERS microbiota Middle East myalgia nausea nervous system neurological occur outbreak Pain pandemic Patient Pneumonia potential mechanism Prophylactic relationship reported respiratory respiratory tract responsible rhinorrhea SARS CoV-2 SARS-CoV-2 severe cases Shock shown sore throat spread to stroke Symptom syndrome Treatment strategies virus WHO [DOI] 10.3389/fmolb.2020.606779 PMC 바로가기 [Article Type] Molecular Biosciences
Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory AxisMicrobiology Published on 2020-09-222022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome approach axis Basis Can cell types changes in coronavirus Coronavirus infectious disease 2019 COVID-19 Diagnostic method ENCODE homeostasis host cells Human human cells induce infected cells Infectious disease insight Like mass-spectrometry modulating molecular multifunctional protein nasal olfactory olfactory dysfunction patients with COVID-19 proteomic proteomics replicate RNA viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus-2 Smell triggered [DOI] 10.3389/fmicb.2020.02101 PMC 바로가기 [Article Type] Microbiology
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 AxisPharmacology Published on 2020-09-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome age aging alteration Analysis analyzed assessment association attrition axis CDKN1C cellular senescence chronic obstructive chronic obstructive pulmonary diseases contribute COPD coronavirus COVID-19 COX10 COX18 differentially expressed DNA damage DPP4 ERCC1 Factor FEN1 FIS1 furin GADD45A GADD45B Gene Expression HAT1 HSPD1 Human human lung tissue Idiopathic pulmonary fibrosis immunoblot Infection Infectious disease Inflammatory IPF lung Lung diseases mechanism Mitochondria mitochondrial Mitochondrial function NBN NFATC1 NOX4 Older PARP1 Patient patients PCNA pharmacological target platform processed progression protease Protein PTEN pulmonary disease pulmonary fibrosis Quality control RAD17 receptor ACE2 regulate Result RHOT2 RNA SARS-CoV-2 senescence SIRT6 slight increase SLX4 Smokers subject subjects target gene Target genes telomere TERT the SARS-CoV-2 TMPRSS2 TNKS2 Total Transcription UCP2 [DOI] 10.3389/fphar.2020.584637 PMC 바로가기 [Article Type] Pharmacology
Applied Clinical Pharmacology in a Crisis: Interleukin-6 Axis Blockade and COVID-19위기의 응용 임상 약리학: 인터루킨-6 축 차단 및 COVID-19Article Published on 2020-09-012022-09-12 Journal: Clinical Pharmacology and Therapeutics [Category] 진단, [키워드] axis clinical coronavirus disease COVID-19 global pandemic hospitals Mitigation Pharmacology public health resource [DOI] 10.1002/cpt.1931 PMC 바로가기 [Article Type] Article