A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients특정 저밀도 호중구 개체군은 입원한 COVID-19 환자의 과응고 및 질병 중증도와 상관관계가 있습니다Research Article Published on 2021-05-102022-09-10 Journal: JCI Insight [Category] SARS, 바이오마커, [키워드] activated acute respiratory distress acute respiratory distress syndrome ARDS Asymptomatic Bronchoalveolar lavage fluid cause CD16 CD38 CD44 Cell changed circulating circulation clinical disease Coagulation Coagulopathy contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Critical disease CXCR3 cytokine cytokine production D-dimer demonstrated develop disease severity disease status exhibiting expressing expression ferritin Frequency hospitalized COVID-19 patient IL-6 Immune cell immune cells immunology Inflammatory life-threatening low-density marker Mild MONITOR neutrophil Neutrophil extracellular traps Neutrophils Patient patients with COVID-19 phagocytic capacity Platelets Pneumonia Prognosis progression proinflammatory gene respiratory respiratory distress SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 severe COVID-19 subset Symptoms syndrome systemic inflammation These cells TNF-α upper respiratory tract venous Viral viral pathogen Viral pneumonia with COVID-19 [DOI] 10.1172/jci.insight.148435 PMC 바로가기 [Article Type] Research Article
Circulating calprotectin as a supporting inflammatory marker in discriminating SARS-CoV-2 infection: an observational studySARS-CoV-2 감염을 식별하는 데 도움이 되는 염증 표지자로서의 순환 칼프로텍틴: 관찰 연구Observational Study Published on 2021-05-062022-09-10 Journal: Inflammation research : official journal of the Eu [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] addition Analysis analyzed calprotectin circulating Circulating calprotectin controls COVID-19 current cutoff value Granulocytes greater hospitalized COVID-19 patient hospitalized COVID-19 patients increase in indication Infection Inflammatory Inflammatory bowel disease inflammatory bowel diseases Inflammatory marker inflammatory status intestinal Laboratory medicine marker Molecular tests objective Patient Perspective plasma positive Predictive Prevent Protein Quantitative Research Result ROC Curve ROC curves RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 patient serum serum and plasma Stool stools subject suspected patient suspected patients systemic inflammatory [DOI] 10.1007/s00011-021-01465-y PMC 바로가기 [Article Type] Observational Study
Prognostic Factors in Hospitalized COVID-19 Patients at the Start of the Pandemic in Colombia: A Retrospective Cohort StudyInternal Medicine Published on 2021-05-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] age Analysis Comorbidities covid prognosis COVID-19 COVID-19 mortality Critical defined determine died disease mortality evaluate explain Factor greater Hospital admission hospitalized COVID-19 patient hospitalized patient hyperinflammation Hyperinflammatory syndrome in-hospital mortality independent information Latin LDH material Mortality multivariate logistic regression NEWS2 objective Older age PaO2/FiO2 ratio Patient patients performed populations Prognostic factor required Result retrospective cohort study SARS CoV-2 score serum Seven severe disease severity Severity of disease Tocilizumab type 2 diabete was performed [DOI] 10.7759/cureus.14865 PMC 바로가기 [Article Type] Internal Medicine
Clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak of the pandemic대유행이 정점에 달했을 때 MERS-CoV 위탁 병원에 입원한 COVID-19 환자의 임상적 특성 및 결과Article Published on 2021-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] 치료기술, [키워드] 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age AST biochemical marker Care case sery Characteristics city clinical Clinical characteristics Co-infection Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 cough COVID-19 creatinine CRP D-dimer death diabete diabetes Dyspnea elevated end-organ damage Fever hospital Hospitalized hospitalized COVID-19 patient hypertension ICU IL-6 individual Infection intensive care intensive care unit King KSUMC less lymphocyte Lymphocyte count lymphopenia male median age MERS MERS-CoV Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus Mortality Most patient Most patients Older Older age outcome pandemic Patient patients required hospitalization polymerase positive real time respiratory syndrome coronavirus reverse transcriptase risk factor Risk factors RT-PCR SARS-CoV-2 Saudi Arabia Seven severe acute respiratory syndrome Coronavirus Severe case severe cases significant increase single-center Symptom symptom duration tested transcriptase troponin Troponin-I university ventilatory support [DOI] 10.1016/j.ijid.2021.03.058 PMC 바로가기 [Article Type] Article
Increased inflammatory markers reflecting fibrogenesis are independently associated with cardiac involvement in hospitalized COVID-19 patients섬유화를 반영하는 증가된 염증 마커는 입원한 COVID-19 환자의 심장 침범과 독립적으로 연관되어 있습니다Article Published on 2021-05-012022-09-11 Journal: The Journal of Infection [Category] MERS, SARS, 바이오마커, [키워드] hospitalized COVID-19 patient Increased Inflammatory marker [DOI] 10.1016/j.jinf.2021.01.017 PMC 바로가기 [Article Type] Article
A pilot double-blind safety and feasibility randomized controlled trial of high-dose intravenous zinc in hospitalized COVID-19 patientsRandomized Controlled Trial Published on 2021-05-012022-10-05 Journal: Journal of medical virology [Category] SARS, 임상, [키워드] Administered appear baseline Concentration COVID-19 COVID-19 patient COVID-19 patients Cutoff Day death deficiency demonstrated double-blind Eligible patients Enrollment evaluate feasibility feasible High-dose hospital discharge hospitalizations hospitalized COVID-19 patient hospitalized patient IIa inhibit intravenous participant Patient patients with COVID-19 per day performed phase pilot study Placebo public health measure Randomized Randomized controlled trial reduced Replication reported Safe SARS-CoV virus Serious Adverse Event serum Side effects Treatment Trial trial protocol with COVID-19 Zinc [DOI] 10.1002/jmv.26895 PMC 바로가기 [Article Type] Randomized Controlled Trial
Prevalence and impact factors of recurrent positive SARS-CoV-2 detection in 599 hospitalized COVID-19 patientsResearch article Published on 2021-05-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] 치료기술, [키워드] acute respiratory syndrome age analysed Characteristics collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demographic characteristics detect enrolled Factor female Hospitalization Hospitalized hospitalized COVID-19 patient individual individuals with COVID-19 initial interquartile range male Nasopharyngeal swab negative RT-PCR objective oropharyngeal swab Patient patients positive positive rate positive RT-PCR Positive test Prevalence produced Recurrent positive Result risk factor RT-PCR SARS-CoV-2 SARS-CoV-2 detection severe acute respiratory syndrome coronavirus 2 significantly higher Swab test tested the median Viral load Viral RNA shedding [DOI] 10.1016/j.cmi.2021.01.028 [Article Type] Research article
Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질의 유도성 발현을 갖는 WAe001-A-58 인간 배아 줄기 세포주의 생성Article Published on 2021-05-012022-09-11 Journal: Stem cell research [Category] SARS, 치료법, [키워드] activate celebrex cell line cell types Comorbidities Comorbidity COVID-19 death discharged embryonic embryonic stem cell expression Generation hospitalized COVID-19 patient hospitalized COVID-19 patients Host karyotype morphology multiple organ multiple organs nucleocapsid nucleocapsid protein PGE prostaglandin prostaglandin E Protein SARS-CoV SARS-CoV-2 SARS-CoV-2 N protein stem cell suggested the SARS-CoV-2 Transcription transcriptionally transposon Treatment [DOI] 10.1016/j.scr.2021.102197 PMC 바로가기 [Article Type] Article
Non-invasive positive pressure ventilation versus endotracheal intubation in treatment of COVID-19 patients requiring ventilatory supportResearch article Published on 2021-05-012022-10-05 Journal: The American journal of emergency medicine [Category] SARS, 치료법, [키워드] 30-Day mortality 95%CI age all-cause mortality Analysis benefit Brooklyn Comorbidities Confidence intervals COVID-19 COVID-19 confirmed patient COVID-19 patient Endotracheal intubation enrolled exposure greater hospital hospitalized COVID-19 patient Hypoxemia Importance initial interquartile ranges Intervention Intubated intubation lower mortality median Mortality mortality rate multivariable analysis multivariable logistic regression multivariable model New York City NIV non-invasive positive pressure ventilation non-invasive ventilation objective Odds ratio outcome oxygen saturation participant Patient patients percentage positive pressure ventilation presenting qSOFA Relevance required Respiratory failure Result secondary setting Sex Support survival Treatment undergo utilization variables ventilator ventilatory support [DOI] 10.1016/j.ajem.2021.01.068 [Article Type] Research article
Effectiveness of hydrogen peroxide as auxiliary treatment for hospitalized COVID-19 patients in Brazil: preliminary results of a randomized double-blind clinical trialRandomized Controlled Trial Published on 2021-05-012022-10-04 Journal: Epidemiology and Health [Category] 임상, [키워드] acute respiratory syndrome adverse effect asked auxiliary clinical trial control group coronavirus coronavirus disease coughing COVID-19 double-blind Dyspnea effective Effectiveness evaluate evaluated Evidence experimental group Fisher exact test group Hospital stay hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hydrogen peroxide Mild moderate MOST mouthwashes nasal Nasal Sprays no significant difference Patient polymerase chain positive Randomized randomly divided reduction in reported Safe SARS-CoV-2 severity Student test Symptom Symptoms tested the patient Treatment were recorded were used [DOI] 10.4178/epih.e2021032 PMC 바로가기 [Article Type] Randomized Controlled Trial