the cell – Page 6 – Communicable Diseases Research

Inhibition of HECT E3 ligases as potential therapy for COVID-19

COVID-19에 대한 잠재적 치료제로서의 HECT E3 리가제의 억제

Article

Published on 2021-03-242022-09-11
Journal: Cell Death & Disease [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료제,

T Cells Plead for Rejuvenation and Amplification; With the Brain’s Neurotransmitters and Neuropeptides We Can Make It Happen

회춘과 증폭을 위한 T 세포 주장; 뇌의 신경전달물질과 신경펩티드로 우리는 그것을 실현할 수 있습니다

Review

Published on 2021-03-222022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘,

[키워드] activate activated acute SARS-CoV-2 infection Adoptive Cell Therapy aging binding Brain Can Cancer Cell cell surface chemotactic chronic infections clinical trials CNS cytokine cytokine secretion damage decrease Depression diagnostic Dopamine Effect Effects Efficacy Ex vivo expressed extravasation Gene Expression Glutamate GnRH high risk Immunotherapy IMPROVE induce Infection infections Inflammation Injury integrin integrin-mediated killing limit microorganism microorganisms Migration Mortality natural Nerve-Driven Immunity nervous Neuropeptide Neuropeptide Y Neuropeptides neurotransmitter Neurotransmitters organization organizations other diseases other treatments overcome PD-1 proliferation protocols receptor Rejuvenation repeated SARS-COV-2 infection senescent Somatostatin Stress suggested System T cell T cells tested the cell therapeutic tissue repair trauma
[DOI] 10.3389/fimmu.2021.617658 PMC 바로가기 [Article Type] Review

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

인간 기도 상피에서 SARS-CoV-2 감염에 대한 단일 세포 종단 분석은 표적 세포, 유전자 발현의 변경 및 세포 상태 변화를 식별합니다

Research Article

Published on 2021-03-172022-08-13
Journal: PLoS Biology [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome air–liquid interface alteration basal and club cells bronchial epithelial cell bystander cells Cell cell tropism cell types cell-intrinsic expression change ciliated cell ciliated cells Club cells coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical Culture cultures drug Drug administration enhanced epithelial cell epithelial cell type epithelial cell types epithelial cells expand expression food Gene Expression Genes HBECs host–viral interaction human airway human airway epithelial human airway epithelial cells Human airway epithelium human bronchial epithelial cells identify IFNs IL-1 IL6 immunofluorescence microscopy induce infected with SARS-CoV-2 Infection interactions interferon interferon-stimulated gene interferon-stimulated genes interferons interleukin ISGs longitudinal analysis novel over Pathogenesis performed polyadenylated viral transcript polyadenylated viral transcripts provide respiratory resulting reveal RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell single-cell analysis target cells the cell Therapeutics Treatment type I type I and type III IFNs type I and type III interferons Type III IFN type III interferon Vaccine Viral viral replication viral transcripts
[DOI] 10.1371/journal.pbio.3001143 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 Entry Related Viral and Host Genetic Variations: Implications on COVID-19 Severity, Immune Escape, and Infectivity

SARS-CoV-2 진입 관련 바이러스 및 숙주 유전자 변이: COVID-19 심각도, 면역 탈출 및 감염성에 미치는 영향

Review

Published on 2021-03-172022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Adhesion Molecule Affect angiotensin antiviral drugs binding Cell contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determine driving drug enzyme escape Evolution genetic diversity genetic risk Genetic variation Genetic variations Genome geographical regions glycoprotein high risk Host host protein human population human populations immune Immune escape Impact in viral Infectivity integrin intercellular intercellular adhesion molecule Mutation Pathogenesis Pathogens Population Positive selection Precision protease Protein Receptor binding domain Research respiratory S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S glycoprotein SARS-CoV-2 variant SARS-CoV-2 variants Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity spike glycoprotein susceptibility the cell the SARS-CoV-2 TMPRSS2 transmembrane transmembrane protease serine 2 Transmissibility Transmission variants Variation Viral viral evolution viral S virus virus transmissibility vital role vital roles
[DOI] 10.3390/ijms22063060 PMC 바로가기 [Article Type] Review

SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcription

SARS-CoV-2 백신 ChAdOx1 nCoV-19 인간 세포주의 감염은 매우 높은 수준의 SARS-CoV-2 S 당단백질 유전자 전사와 함께 낮은 수준의 바이러스 백본 유전자 전사를 나타냅니다

Research

Published on 2021-03-152022-08-13
Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] A549 A549 cell A549 cell line A549 cell lines A549 cells addition Adenovirus approach backbone Cell Cell culture cell line cell lines Cell Nucleus cells ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical trial coding Direct RNA sequencing expected expression Gene Expression Genome globe HEK293 human cell line Infection nucleus phosphoproteome polyadenylation site Protein proteome proteomic proteomics Quantitative recombinant adenovirus Replication Result reveal S glycoprotein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S glycoprotein SARS-CoV-2 vaccine splice supplementary material the cell the SARS-CoV-2 transcript Transcription transcriptomic Vaccine Viral
[DOI] 10.1186/s13073-021-00859-1 PMC 바로가기 [Article Type] Research

Impact of SARS-CoV-2 infection on the recovery of peripheral blood mononuclear cells by density gradient

밀도 구배에 의한 말초 혈액 단핵 세포의 회복에 대한 SARS-CoV-2 감염의 영향

Article

Published on 2021-03-012022-09-01
Journal: Scientific Reports [Category] SARS, 진단,

[키워드] alteration Biological techniques Blood blood donor Cell centrifugation changes in circulating Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients density gradient density gradient centrifugation disease severity Donor early phase early stage exhibited explain forms fraction healthy control Hyperinflammatory Hyperinflammatory response immature Immune-mediated Impact IQR lymphocyte Lymphocytes median Medical research medium Monocytes mononuclear cell mononuclear cells neutrophil Neutrophils Patient PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Predictive reduced respiratory responsible Result SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus infection sedimentation severity shift Spread subset t -test the cell the cells the disease virus infection while Whole blood
[DOI] 10.1038/s41598-021-83950-2 PMC 바로가기 [Article Type] Article

In Silico , In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell Fusion

SARS-CoV-2 스파이크/인간 ACE2 복합체, 바이러스 진입 및 세포 융합 모니터링을 위한 In Silico, In Vitro 및 In Cellulo 모델

Article

Published on 2021-02-252022-09-10
Journal: Viruses [Category] MERS, 변종, 치료기술, 치료제,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral agent Antiviral agents approach approaches assays association binding biochemical BLI Cell Cell fusion cell line cell surface cellular cellular processe cellular processes Clinical research complex Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 detect determine etiologic agent expressing flow cytometry fusion help house in silico in vitro Infection Interaction kinetic Lentiviral vector Model modulation MONITOR monitoring pandemic parameter pseudotyped Replication Research respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Spike Protein S Spike/ACE2 complex the cell the SARS-CoV-2 therapeutic target transduction assay variant Viral viral entry viral spike protein viral spike protein S virus virus entry
[DOI] 10.3390/v13030365 PMC 바로가기 [Article Type] Article

Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro

Iota-carrageenan은 SARS-CoV-2를 중화하고 시험관 내에서 바이러스 복제를 억제합니다

Research Article

Published on 2021-02-172022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, 치료제,

[키워드] absence acute respiratory syndrome administration attachment caused cell entry clinical effectiveness common cold competent coronavirus demonstrated dose duration of symptom effective Endemic in vitro in vitro data inhibit iota-carrageenan lentivirus nasal Nasal spray neutralize neutralized Particle Patient Prophylactic Prophylaxis pseudotyped public health threat reduction Replication respiratory respiratory viruses Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2 spike pseudotyped lentivirus SARS-CoV-2 virus Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severity spike glycoprotein the cell the SARS-CoV-2 therapeutic translated Treatment Vaccine viral replication wild type
[DOI] 10.1371/journal.pone.0237480 PMC 바로가기 [Article Type] Research Article

The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities

다양한 중증도의 코로나바이러스-SARS2 유발 질환 환자에서 면역조절 활성을 갖는 항바이러스제, 약물 및 영양소를 기반으로 한 다단계 치료 접근법의 근거

Full Papers

Published on 2021-02-142022-09-10
Journal: The British Journal of Nutrition [Category] Fulltext, MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome antivirals assumption Cell Characteristics China Clinical sign Clinical signs Compound concerning Corona Corona virus coronavirus COVID-19 cytokine cytokine release Cytokine release syndrome disease drug element Epidemic Europe fat-soluble Genome homology Host immune response identify immune response immunomodulatory activity Immunopathogenesis Infection involved Italy modality Modification modulating outbreak pathogenic mechanism pathogenic mechanisms Patient patients with SARS Pneumonia public health Replication required respiratory SARS SARS infection SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus severity Signs and symptoms Spread stimulate Symptom the cell the SARS-CoV-2 Therapeutic approach therapeutic strategy therapy Transmission Treatment Vitamin vitamins was performed Wuhan
[DOI] 10.1017/S0007114520002913 PMC 바로가기 [Article Type] Full Papers

Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series

COVID-19로 유발된 중증 ARDS 환자 치료를 위한 주산기 조직 유래 중간엽 줄기세포: 사례 시리즈

Clinical Trial

Published on 2021-01-292022-08-13
Journal: Stem Cell Research & Therapy [Category] 바이오마커, 임상, 진단,

[키워드] acute renal and hepatic failure acute respiratory distress syndrome age Allogeneic allogeneic prenatal Alpha ARDS ARDS patients C-reactive protein C-reactive protein (CRP candidate Cardiac arrest Cardiomyopathy case sery cell infusion cell infusions Cell therapy cells chronic lymphocytic leukemia clinical trial CLL CMP Comorbidities Comorbidity Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill develop diabetes diagnosed died discharged distress Dyspnea eight enrolled fatal complication feasibility finding FIVE hepatic failure High dose hospital human umbilical cord MSCs hypertension Hypoxemia ICU ICUs IFN-γ IL-6 IL-6 level IL-6 levels IL-8 IMPROVE Inflammatory biomarker inflammatory biomarkers infusion intensive care unit intensive care units interferon gamma intravenous infusion Large randomized multicenter clinical trials leukemia Leukocytosis lung lymphocyte Lymphocytes mechanical ventilation men mesenchymal stem cell Mesenchymal stem cells Mesenchymal stromal cells MSC MSCs multi-organ failure multicenter one patient outcome Patient patients perinatal tissue Phase 1 PL-MSCs Placenta placental MSC placental MSCs Pneumonia Potential treatment Radiological parameter Radiological parameters Randomized reduce reduced renal reported required respiratory distress Respiratory distress syndrome Safe Sepsis Serious Adverse Event Serious Adverse Events Serum level serum levels Seven severe hypoxemia Significant reduction significant reductions SpO2 stem cell Stem cell therapy supplementary material survivor Survivors syndrome the cell therapeutic potential TNF-α Tolerability Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha UC-MSCs umbilical Umbilical cord women
[DOI] 10.1186/s13287-021-02165-4 PMC 바로가기 [Article Type] Clinical Trial