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[키워드] A phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes acute COVID-19 alleviate alterations AMP-activated protein kinase AMPKAMP-activated protein kinase caloric restriction Cell cell removal cellular senescence chronic disease consequence contribute Coronavirus disease 2019 COVID-19 COVID-19 symptom COVID-19coronavirus disease 2019 COVID-FISA phase 2 placebo-controlled pilot study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes CRcaloric restriction Defense deregulated dysfunction Epigenetic facility for geroscience analysis FGAFacility for Geroscience Analysis generate genomic greater Health ICUIntensive Care Unit IFintermittent fasting ill patients Immune system dysfunction increased risk indicated Infection infections Innate intensive care unit Intercellular communication interfere intermittent fasting Intervention Long-term care facility low-grade inflammation LTCFlong-term care facility mammalian target of rapamycin MCCmultiple chronic conditions MERS-CoVmiddle east respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus mitochondrial dysfunction Mortality mTORmammalian target of rapamycin Multimorbidity multiple chronic conditions NAD+nicotinamide adenine dinucleotide nicotinamide adenine dinucleotide nicotinamide mononucleotide nicotinamide riboside NMNnicotinamide mononucleotide NRnicotinamide riboside Older outcome PACSpostacute sequalae of SARS-CoV-2 infection PAMPspathogen-associated molecular profile factors pathogen-associated molecular profile factors Patient postacute sequalae of SARS-CoV-2 infection predictor reactive oxygen species risk risk factor role ROSreactive oxygen species SARS-CoV-1severe acute respiratory syndrome coronavirus 1 SARS-COV-2 infection SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARSSevere Acute Respiratory Syndrome SASPsenescence-associated secretory phenotype senescence-associated secretory phenotype senescent senescent cell Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 1 severe acute respiratory syndrome coronavirus 2 skilled nursing facility SNFskilled nursing facility susceptibility TGNtranslational geroscience network Translational Geroscience Network viral infection viral infections while WHOWorld Health Organization World Health Organization
[DOI] 10.1016/j.trsl.2021.10.003 [Article Type] Review article